小而密低密度脂蛋白胆固醇在缺血性心脏病的临床研究  

Clinical study of small dense low density lipoprotein cholesterol in patients with ischemic heart disease

作　　者：黄阶胜[1] 李莹莹[1] HUANG Jie-sheng;LI Ying-ying(The department of clinical Laboratory,Zhongshan Hospital of traditional Chinese Medicine,Guangdong Zhongshan 52840)

机构地区：[1]广东省中山市中医院检验科,广东中山528400

出　　处：《医学检验与临床》2018年第8期1-3,21,共4页Medical Laboratory Science and Clinics

基　　金：中山市科技局项目编号：2017a020118.

摘　　要：目的：研究小而密低密度脂蛋白胆固醇（sdLDLC）的在缺血性心脏病的临床应用价值。方法：选取67例缺血性心脏急性期患者设为急性组，33例缺血性心脏病稳定期患者设为稳定组，32例缺血性心脏高危人群设为高危人群组，48例健康体检人员设为对照组，比较各组sdLDLC、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL－C）、同型半胱氨酸（HcY）的检测情况，评价各项指标对缺血性心血管病的诊断价值。结果：sdLDLC、LDL、HCY对照组、高危人群组、稳定组及急性组血清浓度依次升高，任意组间均有统计学差异（P〈0．05），TG、TC、HDL急性组高于其他各组；logstic回归分析显示：sdLDLC、HCY、LDL与缺血性心脏病急性期存在线性回归关系，回归系数b分别为0．934，0．784，0．653，P均〈0.05，对sdLDLC、HCY、LDL与缺血性心脏病急性期行偏相关分析，结果显示sdLDLC、HCY、LDL与缺血性心脏病急性期密切相关，相关系数r为0．476，0．348，0．267，P均〈0．05。结论：sdLDLC与缺血性心脏病急性期发病密切相关，sdLDLC的检测对缺血性心脏病的诊断及预测均有重要的临床应用价值。Objective： To study the importance of small dense low density lipoprotein cholesterol （sdLDLC） in ischemic heart disease. Methods： 67 patients with acute ischemic heart period were set as acute group. 33 patients with ischemic heart disease were set as stable group. 32 cases of high-risk group ofischemic heart were set as high risk group. 48 cases of health examination were set as control group. SdLDLC, triglyceride （TG）, total cholesterol （TC）, high density lipoprotein （HDL-C）, low density lipoprotein （LDL-C） were compared in each group. The detection ofhomocysteine （HCY） and the diagnostic value of various indicators for ischemic cardiovascular disease were evaluated. Results： The serum concentrations ofsdLDLC, LDL, HCY, high risk group, stable group and acute group were higher in turn. There were statistical differences in any group （P〈0.05）. The acute group ofTG, TC and HDL were higher than the other groups. Logstic regression analysis showed that there was linear regression relationship between sdLDLC, HCY, LDL and acute ischemic heart disease, and the regression coefficient B was 0.934,0.784, 0.653, respectively. 〈0.05, partial correlation analysis of sdLDLC, HCY, LDL and acute ischemic heart disease. The results showed that sdLDLC, HCY and LDL were closely related to the acute phase of ischemic heart disease. The correlation coefficient r was 0.476,0.348, 0.267, and P〈0.05. Conclusion： sdLDLC is closely related to the acute stage of ischemic heart disease. The detection ofsdLDLC has important clinical value in the diagnosis and prediction ofischemic heart disease.

关 键 词：缺血性心脏病 小而密低密度脂蛋白胆固醇 甘油三酯 总胆固醇 高密度脂蛋白 低密度脂蛋白 同型半胱氨酸 

分 类 号：R589.2[医药卫生—内分泌]