急性脑梗塞与血清S-100B蛋白的动态变化相关性探讨  

The dynamic changes of the acute cerebral infarction and called S100B protein correlation

作　　者：牛莉莉[1] 马红萍[2] 李建明[1] NIU Lili;MA Hongping;LI Jianming(Department of clinical Laboratory,People＇s Hospital of Changji Hui Autonomous Prefecture,Changji Xinjiang,831100,China;Department of clinical Laboratory,Xingjiang Uygur Autonomous Region people＇s Hospital,Urumqi Xinjiang,830000,China)

机构地区：[1]新疆昌吉州人民医院检验科,新疆昌吉831100 [2]新疆维吾尔自治区人民医院,乌鲁木齐830001

出　　处：《新疆医学》2018年第7期698-700,706,共4页Xinjiang Medical Journal

基　　金：新疆昌吉州科学研究与技术开发计划项目(2017S05-01)

摘　　要：目的观察急性脑梗塞与血清S-100B蛋白水平变化的相关性。方法选取符合标准的30例急性脑梗塞入组,对其血清S-100B蛋白行连续监测,联合影像学检查,以同期20例健康体检人员为对照组,动态观察急性脑梗塞患者血清S-100B的变化。结果以对照组相比,急性脑梗患者血清S-100B水平显著升高,发病3 d达峰值,之后逐渐下降,7 d后趋于正常;在动态监测时段内,血清S-100B水平与梗塞面积呈正相关,脑梗塞面积越大,血清S-100B水平升高越显著r=0.969,并且与小面积脑梗塞患者相比,大面积脑梗塞患者血清S-100B水平升高出现时间较早,且维持时间较长。结论 S-100B蛋白作为急性脑梗塞的血清标志物对急性脑梗塞的诊断与鉴别诊断、病情评价、疗效观察以及预后评估等有重要意义。Objective Observe the dynamic changes of the acute cerebral infarction and called S100B protein correlation. Methods Selection standard of 30 cases of acute cerebral infarction group and the serum S-100B protein dynamic monitoring, combining with head CT examination, understand the infarct size, and compared with 20 cases of control group. Result Serum S-100B protein concentration in patients with acute cerebral infarction was about 3 days to peak, and 7 days after gradually returned to normal, and found the infarct size,the greater the elevated serum concentration of serum S-100B the earlier and the higher value of, return to normal needs the longer; Small area of cerebral infarction significantly lower serum concentrations of serum S-100B of large area cerebral infarction patients. Conclusion S-100B protein as a serum marker of acute cerebral infarction for the differential diagnosis of acute cerebral infarction, condition evaluation, and evaluation of curative effect observation and prognosis, etc have important significance.

关 键 词：急性脑梗塞 S-100B蛋白 

分 类 号：R446.5[医药卫生—诊断学]