饮上用坑道储存水对大鼠胃肠功能的影响  

Influence of tunnel-stored drinking water on gastrointestinal function: an experimental study

作　　者：杨波[1] 吴有军[1] 王颐[1] 吕刚[1] 孙永胜[1] YANG Bo;WU Youjun;WANG Yi;LV Gang;SUN Yongsheng(Department of General Surgery,PLA 309th Hospital,Beijing 100091,China)

机构地区：[1]解放军第309医院普通外科,北京100091

出　　处：《武警医学》2018年第8期790-792,共3页Medical Journal of the Chinese People's Armed Police Force

基　　金：全军“十二五”军事医学创新工程面上项目(13CXZ047)

摘　　要：目的探讨坑道储存水的水质变化情况及其对大鼠胃肠功能的影响。方法对部队日常饮用水及在坑道中储存1、3、6周的水进行水质检测,而后将SD大鼠分为4组,每组10只,分别给予加热煮沸处理的饮用水和坑道储存水饲喂2周,比较各组胃液p H值、胃黏膜前列腺素E2含量、胃黏膜细胞周期和凋亡情况及粪便球杆比。结果随着储存时间延长,水的感官性状指标、一般化学指标、毒理学指标无明显变化,细菌总数逐渐增加;饮用储存3周和6周水的大鼠其胃液p H值以及胃黏膜S期细胞和凋亡细胞比例发生显著改变;储存6周水饲喂的大鼠胃黏膜PGE2水平明显降低;粪便球杆比各组间差异无统计学意义。结论坑道中储存较长时间的水可对胃黏膜造成损害,应采取相关措施加以预防。Objective To investigate the quality of water stored in a tunnel and the impact on the gastrointestinal function of rats. Methods The quality of daily drinking water and water stored in tunnel for one week,three weeks,six weeks was examined before forty SD rats were equally divided into four groups and fed with boiled normal drinking water,water stored in a tunnel for one week,three weeks and six weeks respectively for two weeks. The PH value of gastric juice,fecal cocci/bacillus ratio,amount of prostaglandin E2（ PGE2）,proportion of cells in S phase and apoptotic cells in the gastric mucosa were compared between the four groups.Results No changes were observed in sensory property indexes,general chemical indexes or toxicological indexes over time,but the total bacterial count tended to gradually increase. However,significant changes in the PH value of gastric juice,in the proportion of cells in S phase and in apoptotic cells in the gastric mucosa were found in rats that had drunk water stored in a tunnel for three weeks and six weeks. The level of PGE2 in the gastric mucosa significantly decreased in rats which were administered with water stored for six weeks, but there was no statistically significant significance in the fecal cocci/bacillus ratio between these groups.Conclusions Drinking water stored in tunnels is a potential risk factor that impairs the gastric mucosa so that effective measures should be taken.

关 键 词：坑道 水 胃肠道 

分 类 号：R821.6[医药卫生—临床医学]