炙甘草汤对大鼠实验性心肌缺血再灌注损伤的影响  

EHects of Zmgancao Decoction on MyocardialInjury Induced by Experimental Ischemia一reperfu-sion in Isolated Rat Hearts

作　　者：胡因铭[1] 陈奇[1] 张文然 

机构地区：[1]江西中医学院

出　　处：《中国实验方剂学杂志》1995年第1期18-21,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：本文在Ｌａｎｇｅｎｄｏｒｆｆ装置上观察了炙甘草汤对大鼠离体心脏冠状动脉前降支结扎再灌注损伤的影响。结果表明，炙甘草汤（８ｇ／Ｌ）能显著降低结扎期室性心动过速（ＶＴ），再灌注期室颤（ＶＦ）和心律失常总发生率，抑制心肌细胞中磷酸肌酸激酶（ＣＰＫ）和乳酸脱氢酶（ＬＤＨ）的释放，炙甘草汤２，４，８ｇ／Ｌ均能显著降低再灌注心肌组织中脂质过氧化物丙二醛（ＭＤＡ）含量、增强过氧化物歧化酶（ＳＯＤ）活性。炙甘草汤的以上作用与钙拮抗剂维拉帕米（Ｖｅｒａｐａｍｉｌ，０．５μｍｏｌ／Ｌ）作用相似。Using Langendorff’s device for coronary artery ligation and reper-fusion,effects of Zhigancao decoctoin on myocardial damage induced by ligating and reperfusing descending anterior branch of coronary artery were studied in iso-lated rat hearts.Zhigancao decoction at a dose of 8g/L was found to produce a marked reduction in the incidence of VT during ligation(ishenua ,VF after reperfusion, and arrhythmia in rats.It also remarkably inhibited CPK or LDH release from mvocardial cells. In addition, Zhigancao decoction at doses of 2,4,and 8g/L appeared to increase the activity of SOD and decrease the level of MDA in myocardial tissue. All these effects were similar to those of verapamil(0.5μmol/L).

关 键 词：心肌缺血 再灌注损伤 炙甘草汤 心肌缺血再灌注 心律失常 乳酸脱氢酶 磷酸肌酸激酶 

分 类 号：R259.414[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]