维生素D受体基因Fok I、Bsm I多态性与慢性阻塞性肺疾病易感性的关系研究  

Association between polymorphism of Vitamin D receptor gene Fok I,Bsm I and susceptivity of chronic obstructive pulmonary disease

作　　者：顾文超[1] 袁亚平[1] 杨华[1] 吴浩[1] 王林宣 唐志君[1] 邓国平[1] 李珊珊[1] GU Wen-chao;YUAN Ya-ping;YANG Hua;WU Hao;WANG Lin-xuan;TANG Zhi-jun;DENG Guo-ping;LI Shan-shan(People＇s Hospital of Shanghai Pudong District,Shanghai 201299,China)

机构地区：[1]上海市浦东新区人民医院呼吸科,上海201299

出　　处：《临床肺科杂志》2018年第12期2144-2147,共4页Journal of Clinical Pulmonary Medicine

基　　金：上海市浦东新区卫生系统领先人才培养计划(No PWRI2014-04);上海市浦东新区卫生系统重点学科建设资助(No PWZxk2017-24)

摘　　要：目的探讨维生素受体(VDR)基因Fok I(rs2228570)位点和Bsm I(rs1544410)位点多态性与慢性阻塞性肺疾病(COPD)发病率之间的关系。方法收集2015年06月-2016年12月,入住上海市浦东新区人民医院呼吸科,COPD患者80例,同期住院的非COPD患者45例,运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对其血样DNA进行VDR基因Fok I(rs2228570)位点和Bsm I(rs1544410)位点多态性进行检测,分析其基因型、基因频率,并与临床特征比对,统计分析其相关性。结果 COPD患者与非COPD患者(对照组)比较,Fok I位点基因型分布存在明显差异(P=0. 021),Bsm I位点基因型分布在COPD患者与非COPD患者中无显著差别(P=0. 672)。结论 COPD发病率与VDR基因rs2228570(Fok I)基因型分布具有相关性,但与rs1544410(Bsm I)位点多态性无明显相关性。Objective To investigate the association between polymorphism of Vitamin D receptor genes rs2228570 and rs1544410 （Fok I and Bsm I） and susceptivity of chronic obstructive pulmonary disease （COPD）. Methods A total of 80 COPD patients and 45 concurrent patients without COPD were involved in this study from June, 2015 to December 2016. By PCR-RFLP technique,the VDR gene polymorphisms of blood samples were tested. Results There was significant difference in genotype frequency between COPD patients and non-COPD patients in VDR gene SNP locus Fok I （ P =0.021）,but no significant difference was found in SNP locus Bsm I （ P =0.672）. Conclusion COPD morbidity is correlated with VDR gene polymorphism in SNP locus Fok I but not Bsm I.

关 键 词：维生素D受体 FOK I基因多态性 BSM I基因多态性 慢性阻塞性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统] R440[医药卫生—内科学]