FBP和OSEM对正常人脑内多巴胺转运体分布半定量值影响的研究  

Effects of the different PET image reconstruction methods on distribution of dopamine transporter in healthy human brain

作　　者：朱毓华 鲁佳荧 张慧玮 葛璟洁 吴平 鲍伟奇 琚紫昭 王坚 管一晖[4] 左传涛[4] Zhu Yuhua;Lu Jiaying;Zhang Huiwei;Ge Jingjie;Wu Ping;Bao Weiqi;Ju Zizhao;Wang Jian;Guan Yihui;Zuo Chuantao(PET Center,Huashan Hospital,Fudan University,Shanghai 200235,Chin;Department of Nuclear Medicine,Huashan Hospital,Fudan University,Shanghai 200235,China;Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200235,China;Institute of Functional and Molecular Medical Imaging,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院PET中心,上海200235 [2]复旦大学附属华山医院核医学科,上海200235 [3]复旦大学附属华山医院神经内科,上海200235 [4]复旦大学医学功能与分子影像研究所,上海200040

出　　处：《国际放射医学核医学杂志》2018年第5期409-413,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81671239、81571345、81771372、81701250）;国家重点研发计划（2016YFC1306403、2016YFC1306500）;上海市青年科技英才扬帆计划（16YF1415400）

摘　　要：目的 研究不同PET重建方法对正常人脑内多巴胺转运体（DAT）分布半定量值的影响.方法 将2014年3月至2015年6月期间41例健康受试者（正常人）的^11C-甲基-N-2β-甲基酯-3β-（4-氟-苯基）托烷（11C-CFT）PET图像分别进行滤波反投影法（FBP）和有序子集最大期望值迭代法（OSEM）重建,自动勾画尾状核、壳核前部和后部等感兴趣脑区,以缺乏DAT分布的顶枕皮质作为参考区,按公式计算DAT分布的半定量值.DAT分布半定量值的组间比较采用配对t检验,相关性分析采用Pearson相关分析法.结果 基于OSEM重建的PET图像中DAT分布半定量值分别为：尾状核（1.77～2.15）、壳核前部（2.17～2.39）、壳核后部（1.71～2.06）;基于FBP重建的PET图像中DAT分布半定量值分别为：尾状核（1.68～2.10）、壳核前部（2.07～2.37）、壳核后部（1.62～1.96）.基于OSEM重建的PET图像中双侧尾状核、壳核前部及后部的DAT分布半定量值均显著高于基于FBP重建的PET图像,且两者间的差异均有统计学意义（t=9.658～15.859,均P=0.000）.Pearson相关性分析结果显示,基于OSEM与FBP重建的PET图像的DAT分布半定量值在双侧尾状核、壳核前部及后部均呈显著正相关（R^2=0.907 ～0.951,均P=0.000）.基于OSEM与FBP重建的PET图像中双侧尾状核、壳核前部及后部DAT分布半定量值均呈现随年龄增长逐渐减低的趋势.结论 不同PET重建方法获得的正常人脑内DAT分布半定量值存在显著差异,在多中心或纵向研究中需要保持PET图像重建方法的一致性.Objective To study the effect of the reconstruction method on the semi-quantitative distribution of dopamine transporter （DAT） in the brain,2β-carbomethoxy-3β-（4-fluorophe-nyl）-（N-11C-methyl） tropane （11C-CFT） PET images of healthy subjects were reconstructed by different PET reconstruction methods.Methods From March 2014 to June 2015,the ^11C-CFT PET images of 41 healthy subjects were reconstructed by filtering back projection（FBP） method and ordered subsets expectation maximization（OSEM） iterative method.The brain regions of interest （ROI）,namely,caudate nucleus,anterior putamen,and posterior shell nucleus,were automatically sketched with the parietal and occipital cortex lacking of DAT distribution as reference regions.The semi-quantitative value of DAT distribution was calculated using the following formula：radioactivity count of ROI/radioactivity count of parietal and occipital cortex-1.Paired t-test was used to compare the semi-quantitative values of DAT distribution.Correlation analysis was performed using the Pearson correlation analysis.Results The values of DAT distribution based on OSEM were as follows：caudate nucleus （1.77-2.15）,anterior putamen （2.17-2.39）,and posterior putamen （1.71-2.06）.The values of DAT distribution based on FBP were as follows：caudate nucleus （1.68-2.10）,anterior putamen （2.07-2.37）,and posterior putamen （1.62-1.96）.In the bilateral caudate nucleus and anterior and posterior putamen,the 11C-CFT of DAT distribution by OSEM was significantly higher than that by FBP（t=9.658-15.859,all P=0.000）.The Pearson correlation analysis showed that the semi-quantitative values of DAT distribution by FBP and OSEM were positively correlated with each other in the bilateral caudate nucleus and anterior and posterior putamen （R^2=0.907-0.951,all P=0.000）.The DAT distribution by OSEM and FBP decreased with aging in the caudate nucleus and anterior and posterior putamen.Conclusions A significant difference was found in the semi-qua

关 键 词：多巴胺质膜转运蛋白质类 正电子发射断层显像术 滤波反投影 迭代 

分 类 号：R816.1[医药卫生—放射医学]