金纳米棒作为新型CT对比剂的体外CT成像探索  

In vitro CT imaging of gold nanorods as novel CT contrast agents

作　　者：尹伟[1] 刘日[1] 王敏杰[1] 弓静[1] Yin Wei;Liu Ri;Wang Minjie;Gong Jing(Department of Radiology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)

机构地区：[1]第二军医大学附属医院长海医院影像医学科,上海200433

出　　处：《国际放射医学核医学杂志》2018年第5期430-435,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81400368）

摘　　要：目的 探讨金纳米棒作为新型CT对比剂的体外CT成像参数.方法 采用金种子和生长液的方法制备金纳米棒.将聚乙二醇修饰的金纳米棒及非离子型碘对比剂（优维显370）分别制成8种浓度梯度（0、0.1、0.2、0.4、0.6、0.8、1.0、2.0 mg/mL）的溶液.将不同浓度的金纳米棒溶液在空气中及水浴中、不同管电压（80～140kV）、不同毫安秒（50～400 mAs）等条件下进行体外CT扫描成像,观察其显影效果并测量不同浓度金纳米棒与碘对比剂的CT值.结果 ①不同浓度的金纳米棒溶液,水中扫描的CT值最接近真实值,而空气中CT值偏低;②管电压越低,金纳米棒溶液的CT值越高,当溶液浓度为2.0 mg/mL时,不同管电压下的信噪比差异均较明显;③图像质量与毫安秒呈正相关,但当毫安秒≥300 mAs时,图像质量不再有显著变化.④当扫描参数为80 kV、300 mAs时,随着浓度的增加,金纳米棒与碘对比剂的CT值也升高,并呈高度正相关关系（r=0.990、0.994,均P＜0.05）,但二者的CT值差异越来越大,金纳米棒较碘对比剂有更高的对比度.结论 金纳米棒具有比现有CT对比剂更优的显影特征,体外CT在80 kV、300 mAs以及水浴扫描条件下有助于获得优良的显影图像.Objective To investigate the in vitro CT imaging parameters of gold nanorods as novel CT contrast agents.Methods Gold nanorods were prepared with a gold seed and a growth solution.PEG-modified gold nanorods and non-ionic iodine contrast agent were configured into eight concentrations（0,0.1,0.2,0.4,0.6,0.8,1.0,2.0 mg/mL）.The different concentrations of the gold nanorod solutions in air and water bath were subjected to in vitro CT scanning imaging at different tube voltages（80-140 kV） and milliamp seconds（50-400 mAs）.The development effect was observed,and the CT value was measured.Results （1） At different concentrations of the gold nanorod solutions,the CT value scanned in water is the closest to the true value,whereas the CT value in air is low.（2） The lower the tube voltage is,the higher the CT value of the gold nanorod solution is.At a solution concentration of 2.0 mg/mL,the difference in the signal-to-noise ratio at different tube voltages is evident.（3） The image quality is positively correlated with mAs,but the image quality is not significantly changed at ≥ 300 mAs.（3） At 80 kV and 300 mAs,the CT values of the gold nanorods and the iodine contrast agent increase as the concentration increases and show a highly positive correlation（r=0.990,0.994,,both P〈0.05）.The difference in CT values between the two agents increases,and the contrast of the gold nanorods is higher than that of the iodine contrast agents.Conclusion Gold nanorods exhibit superior imaging characteristics to those of existing CT contrast agents.When gold nanorods are scanned with iCT at 80 kV and 300 mAs and under water bath conditions,an excellent image quality can be achieved.

关 键 词：纳米粒子 体层摄影术 X线计算机 造影剂 

分 类 号：R814[医药卫生—影像医学与核医学]