CRISPR基因编辑技术发展态势分析  

Trends and development analysis of genome editing technology focusd on CRISPR

作　　者：王慧媛[1] 范月蕾[1] 褚鑫[2] 于建荣[1] WANG Hui-Yuan;FAN Yue-Lei;CHU Xin;YU Jian-Rong(Shanghai Information Center of Life Science,Chinese Academy of Sciences,Shanghai 200031,China;Bureau of Major R＆D Programs,Chinese Academy of Sciences,Beijing 100864,China)

机构地区：[1]中国科学院上海生命科学信息中心,上海200031 [2]中国科学院重大科技任务局,北京100864

出　　处：《生命科学》2018年第9期1019-1029,共11页Chinese Bulletin of Life Sciences

基　　金：中国科学院学部研究项目"基因编辑伦理问题研究(Y719I2A001)"

摘　　要：近年来,以CRISPR为代表的基因组编辑技术发展迅速,围绕该技术的一系列基础和应用研究成为全球研究热点。现基于Web of Science信息检索平台中的SCI-Expanded来源数据库,结合文献计量、重要进展以及相关的伦理讨论,对CRISPR为代表的基因组编辑技术发展态势进行分析,为相关研究提供参考。In recent years, new genome editing technologies based on novel and efficient DNA targets have been widely applied in different biological and life science research area, especially the clustered regulatory interspaced short palindromic repeats CRISPR/Cas-based RNA-guided DNA endonucleases（CRISPR/Cas）. In this paper, based on SCI-Expanded database in Web of Science,trend and development of genome editing technology research focused on CRISPR are analyzed through bibliometric methods.

关 键 词：基因编辑 CRISPR 文献计量 伦理 

分 类 号：G353[文化科学—情报学] Q78[生物学—分子生物学]