VWC2L基因rs13428663多态性与中国汉族扩张型心肌病易感性的关系  

Association between rs13428663 polymorphism of VWC2L gene and risk of dilated cardiomyopathy in Chinese Han population

作　　者：施小晴 王俊杰 彭梦乐 李冰洁[1] 袁莹莹 秦东春[1] SHI Xiaoqing;WANG Junjie;PENG Mengle;LI Bingjie;YUAN Yingying;QIN Dongchun(Department of Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Department of Cardiovascular Medicine,Huaibin First People＆ Hospital,Xinyang,Henan 464400;Department of Clinical Laboratory,the Third People＇s Hospital of Henan Province,Zheng-zhou 450006)

机构地区：[1]郑州大学第一附属医院检验科,郑州450052 [2]淮滨县第一人民医院心内科,河南信阳464400 [3]河南省直第三人民医院检验科,郑州450006

出　　处：《郑州大学学报（医学版）》2018年第5期634-637,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关基金资助项目(172102310077)

摘　　要：目的:评估VWC2L基因rs13428663和HSPB7基因rs1739843与中国汉族扩张型心肌病(DCM)人群易感性的关系。方法:采用基质辅助激光解析电离飞行时间质谱进行基因分型,对中国汉族人群(593例病例和513例对照)进行分析,以探讨rs13428663和rs1739843与DCM的关系。结果:VWC2L基因rs13428663位点G等位基因频率在病例组和对照组间比较差异有统计学意义(OR=1.231,95%CI=1.007~1.504,P=0.042)。此外,该位点在加性模型(OR=1.231,95%CI=1.007~1.504,P=0.042)与DCM易感性有关。结论:VWC2L基因rs13428663多态性可能与中国汉族人群DCM易感性有关。Aim： To evaluate the association between rs13428663 in VWC2 L gene or rs1739843 in HSPB7 gene with dilated cardiomyopathy（ DCM） in the Chinese Han population. Methods： A total of 593 DCM patients and 513 controls were involved in the study,genotyping was performed by matrix-assisted laser desorption/ionization time of flight mass spectrometry. The prevalence of polymorphisms of rs13428663 and rs1739843 in the Chinese Han population with DCM was explored. Results： G allele frequency on rs13428663 of VWC2 L had statistical difference between DCM group and control group（ OR = 1. 231,95% CI = 1. 007-1. 504,P = 0. 042）. Besides,an association between rs13428663 and risk of DCM was observed in the additive model（ OR = 1. 231,95% CI = 1. 007-1. 504,P = 0. 042）. Conclusion： There may be an association between rs13428663 polymorphism of VWC2 L gene and risk of DCM in Chinese Han population.

关 键 词：VWC2L基因 扩张型心肌病 基因多态性 中国汉族 

分 类 号：R542.2[医药卫生—心血管疾病]