hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells  

作　　者：Xinyu Zhu Min Li Xiaojun Xu Rui Zhang Xiaofei Zhang Zhuo Ma Jingze Lu Tao Xu Junjie Hou Eli Song 

机构地区：[1]Key Laboratory of Molecular Biophysics of the Ministry of Educa-tion, College of Life Science and Technology, Huazhong Universityof Science and Technology, Wuhan 430074, China [2]National Laboratory of Biomacromolecules, CAS Center forExcellence in Biomacromolecules, Institute of Biophysics, ChineseAcademy of Sciences, Beijing 100101, China [3]College of Life Sciences, University of Chinese Academy ofSciences, Beijing 100049, China

出　　处：《Protein & Cell》2018年第10期896-901,共6页蛋白质与细胞（英文版）

摘　　要：Dear Editor, Endocytosis is a crucial process employed by cells to internal- ize nutrients and turnover membrane components and is essential for many functions, including nutrient uptake, signal transduction, cytokinesis, morphogenesis, cell adhesion and migration. Endocytosis is classified as clathrin-dependent endocytosis （CDE） or clathrin-independent endocytosis （CIE） according to its dependence on clathrin. Several different CIE pathways have been proposed, including caveolin-dependent endocytosis, flotillin-dependent endocytosis, the clathrin-inde- pendent carrier pathway, ARF6-dependent endocytosis, phagocytosis, macropinocytosis, the IL2RI3 pathway （Doherty and McMahon, 2009）, the newly identified fast endophilin-me- diated endocytosis pathway （Boucrot et al., 2015） and the EGFR-NCE pathway （Caldieri et al., 2017）.Dear Editor, Endocytosis is a crucial process employed by cells to internal- ize nutrients and turnover membrane components and is essential for many functions, including nutrient uptake, signal transduction, cytokinesis, morphogenesis, cell adhesion and migration. Endocytosis is classified as clathrin-dependent endocytosis （CDE） or clathrin-independent endocytosis （CIE） according to its dependence on clathrin. Several different CIE pathways have been proposed, including caveolin-dependent endocytosis, flotillin-dependent endocytosis, the clathrin-inde- pendent carrier pathway, ARF6-dependent endocytosis, phagocytosis, macropinocytosis, the IL2RI3 pathway （Doherty and McMahon, 2009）, the newly identified fast endophilin-me- diated endocytosis pathway （Boucrot et al., 2015） and the EGFR-NCE pathway （Caldieri et al., 2017）.

分 类 号：Q959.8[生物学—动物学] TK16[动力工程及工程热物理—热能工程]