可溶性CD14与冠心病的关系探讨  

The Relationship Between Soluble CD14 and Coronary Heart Disease

作　　者：刘颖[1] 邹艳惠[1] 李默玉 陈立涛[1] 张雪莲[1] 王鑫[1] 白玫[1] 张广成[1] LIU Ying;ZOU Yan-hui;LI Mo-yu;CHEN Li-tao;ZHANG Xue-lian;WANG Xin;BAI Mei;ZHANG Guang-cheng(Department of Cardiology,Jilin Provincial People＇s Hospital,Changchun,Jilin Province,130021 China)

机构地区：[1]吉林省人民医院心内科,吉林长春130021

出　　处：《中外医疗》2018年第26期53-54,57,共3页China & Foreign Medical Treatment

基　　金：吉林省卫生厅课题:冠心病与CD14相关性及他汀类药物干预作用的研究(2010ZC03)

摘　　要：目的探讨可溶性CD14与冠心病之间的关系。方法方便选取2017年2月—2018年2月该院收治的冠心病患者130例,按照疾病类型分为稳定性心绞痛组、不稳定心绞痛组,急性心肌梗死组。检测各组患者血浆内s CD4、CRP、vWF的水平,探究可溶性CD14与冠心病的关系。结果 AMI组s CD14、vWF、CRP水平分别为(12.24±8.23)μg/mL、(175.25±35.91)%、(10.35±6.15)mg/L,明显高于UA组(9.15±7.58)μg/m L、(153.66±35.91)%、(6.51±4.28)mg/L,但两组间数值差异无统计这意义(P>0.05),而AMI组与UA组明显高于SA组、对照组(P<0.05);将s CD14与血浆vWF、CRP间行相关Pearson相关系数研究,结果发现,s CD14与v WF、CRP之间皆有直线关系(t=0.57、0.31,P<0.05)。结论sCD14的提高可以导致vWF、CRP的升高,前者可以增强体内炎症反应,并使斑块破裂,后者会加速血管内皮细胞的损害,两者共同作用导致血栓形成,增加了冠心病的发病率。Objective To investigate the relationship between soluble CD14 and coronary heart disease. Methods A total of 130 patients with coronary heart disease admitted to the hospital from February 2017 to FebruatT 2018 were convenient selected enrolled. The patients were divided into stable angina peetoris group, unstable angina peetoris group and acute myocardial infarction group according to the type of disease. The levels of sCD4, CRP and vWF in plasma were detected in each group, and the relationship between soluble CD14 and coronary heart disease was explored. Results The levels of sCD14, vWF and CRP in AMI group were （12.24±8.23）μg/mL,（175.25±35.91）%, and （10.35±6.15） mg/L, which were significantly higher than UA group （9.15±7.58）μg/L, （153.66±35.91）%, （6.51±4.28）rag/L, but there was no significant difference between the two groups （P〉0.05）, while AMI group and UA group were significantly higher than SA group and control group （P〈0.05）; sCD14 was correlated with plasma vWF and CRP. Correlation coefficient study showed that there was a linear re- lationship between sCD14 and vWF and CRP（r=0.57, 0.31, P〈0.05）. Conclusion The increase of sCD14 can lead to the in- crease of vWF and CRP. The former can enhance the inflammatory reaction in the body and rupture the plaque. The latter will accelerate the damage of vascular endothelial cells. The combination of the two causes thrombosis and increases the in- cidence of coronary heart disease rate.

关 键 词：可溶性CD14 冠心病 内皮细胞 

分 类 号：R541.4[医药卫生—心血管疾病]