TNF-α与常见血管类疾病的关系  

Correlation of TNF-α to vascular diseases: a literature review

作　　者：江海宙 苏兰利[1] JIANG Hai-zhou; SU Lan-li;(College of Bioengineering, Henan University of Technology, Zhengzhou 450001, China)

机构地区：[1]河南工业大学生物工程学院,河南郑州450001

出　　处：《健康研究》2018年第5期529-531,537,共4页Health Research

基　　金：河南省教育厅自然科学项目(15A230008);河南工业大学高层次人才项目(2013BS027);河南工业大学科教融合项目

摘　　要：肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)是一种重要的前炎症因子,调节机体的免疫反应。TNF-α不仅参与机体的炎症反应,还参与血管的损伤与新血管的生成。TNF-α对血管效应的复杂性受机体状况等多种因素影响。文章就TNF-α与常见血管损伤与生成疾病关系的研究进行综述。Tumor necrosis factor-α（ TNF-α）,mainly released by mononuclear phagocyte,is a kind of proinflammatory cytokine. Its function is to regulate human inflammatory response. TNF-α can not only injure blood vessel and cause corresponding diseases,but also promote angiogenesis and then result in tumor deterioration. Complex effects of TNF-α on blood vessel depend on various factors. This paper presents a review of the researches on TNF-α in vascular injury,angiogenesis and its diseases.

关 键 词：肿瘤坏死因子-Α 血管损伤 血管生成 

分 类 号：R543[医药卫生—心血管疾病]