环境双酚A与生殖系统恶性肿瘤相关性的研究现状与进展  

Advances in researches of environmental bisphenol A and reproductive system malignancies

作　　者：单菲菲 吴茵茵[1] SHAN Fei-lei; WU Yin-yin(School of Medicine, Hangzhou Normal University, Hangzhou 310036, China)

机构地区：[1]杭州师范大学医学院,浙江杭州310036

出　　处：《健康研究》2018年第5期532-537,共6页Health Research

基　　金：浙江省自然科学基金青年基金(LQ16H260002);杭州市社会发展自主申报项目(20160533B02)

摘　　要：双酚A(bisphenol A,BPA)是一种常见的环境内分泌干扰物,具有显著的类雌激素作用。BPA能通过改变相关基因的表达,或与相关受体结合,从而影响雌激素相关肿瘤细胞的增殖。大量研究提示BPA暴露可能是引起乳腺癌、卵巢癌、前列腺癌和子宫内膜癌等生殖系统恶性肿瘤的危险因素。文章对近年来双酚A与乳腺癌、卵巢癌、前列腺癌和子宫内膜癌等生殖系统恶性肿瘤的相关性研究进行了系统阐述。As one common environmental endocrine disruption,bisphenol A（ BPA） has significant estrogen-like effect.BPA can influence the proliferation of estrogen-related tumor cells through changing the expression of related genes,or the combination of related receptors. Evidence from multiple studies suggested that BPA exposure is a possible risk factor contributing to reproductive system malignancies,such as breast cancer,ovarian cancer,prostate cancer,and endometrial cancer. The paper presents a review of the studies conducted over recent years on the role of BPA in the development of reproductive system malignancies,such as breast cancer,ovarian cancer,prostate cancer,and endometrial cancer.

关 键 词：双酚A 生殖系统恶性肿瘤 内分泌干扰作用 雌激素受体 

分 类 号：R181[医药卫生—流行病学]