恩替卡韦治疗肝炎对慢性乙肝患者血清中Ⅳ型胶原(CⅣ)含量变化的影响  

Effect of Entecavir Treatment of Hepatitis on the Changes of Constant of CⅣ in Serum of Patients with Chronic Hepatitis B

作　　者：马洪波[1] 刘芳[1] MA Hong-bo;LIU Fang(Department of Infection,Tancheng First People＇s Hospital,Linyi,Shandong Province,276199 China)

机构地区：[1]山东省郯城县第一人民医院感染科,山东临沂276199

出　　处：《系统医学》2018年第18期49-51,共3页Systems Medicine

摘　　要：目的分析恩替卡韦治疗肝炎对慢性乙肝患者血清中Ⅳ型胶原(CⅣ)含量变化的影响。方法从该院2015年7月—2017年10月收治的慢性乙肝患者中抽选78例,抽样分成两组:恩替卡韦疗法实验组,共39例;拉米夫定疗法对照组,共39例,统计两组的治疗效果。结果实验组治疗后的病毒载量为(3.10±0.75),明显低于对照组的(4.09±0.86),差异有统计学意义(t=5.418,P<0.05)。实验组、对照组患者治疗后的ALT、Alb指标明显变化,差异有统计学意义(P<0.05),在治疗前,对照组和实验组的前体质量、腹围、24 h尿量等指标差异无统计学意义(P>0.05);实验组治疗后体质量为(59.62±6.42)kg、腹围为(88.52±11.23)cm、24 h尿量为(1 140.36±16.77)mL均显著优于对照组,差异有统计学意义(P<0.05)。治疗后实验组患者的CⅣ(94.22±10.95)mg/L明显低于对照组的(112.92±12.18)mg/L,差异有统计学意义(t=3.841,P<0.05)。结论给予慢性乙肝患者恩替卡韦疗法效果突出,可减少病毒载量,降低血清中Ⅳ型胶原含量,增强疗效,值得借鉴。Objective To analyze the effect of entecavir treatment of hepatitis on the changes of constant of C IV in serum of patients with chronic hepatitis B. Methods 78 cases of patients with chronic hepatitis B in our hospital from July 2015 to October 2017 were selected and divided into two groups with 39 cases in each, the experiment group used the entecavir therapy, while the control group used the lamivudinevir therapy, and the treatment effect of the two groups was counted. Results After treatment, the viral loading in the experiment group was obviously lower than that in the control group [（3.10±0.75） vs （4.09±0.86） ], and the difference was statistically significant （t=5.418,P〈0.05） , after treatment, the ALTAlb in the two groups were obviously changed, and the difference was statistically significant （P〈 0.05） , before treatment, the differences in the precursor mass, abdominal circumference, 24 h urine volume between the two groups were not statistically significant （P〉0.05）; after treatment, the precursor mass, abdominal circumference, 24 h urine volume after treatment in the experiment group were respectively （59.62±6.42） kg,（88.52±11.23）cm,（1 140.36±16.77）mL, which were obviously better than those in the control group, and the difference was statistically sig nificant （P〈0.05）, after treatment, the C IV in the experiment group was obviously lower than that in the control group [（94.22±10.95）mg/L vs （112.92±12.18）rag/L], and the difference was statistically significant（t=3.841,P〈0.05）. Conclu sion The effect of entecavir treatment of patients with chronic hepatitis B is outstanding, which can reduce the viral loading, reduce the constant of CIV in serum and increase the curative effect, and it is worth reference.

关 键 词：恩替卡韦 Ⅳ型胶原 肝炎 临床效果 

分 类 号：R256[医药卫生—中医内科学]