离子交换型微球栓塞剂的载药及可视化研究  

Research Progress in Drug Loading and Visualization of Ion-exchange Microsphere Embolic Agents

作　　者：李旭丰 付纪军 严立标 余宗峻 黄剑文 杨海南 黄玉刚 杜玲然 LI Xu-feng;FU Ji-jun;YAN Li-biao;YU Zong-jun;HUANG Jian-wen;YANG Hai-nan;HUANG Yu-gang;DU Ling-ran(Key Laboratory of Molecular Talget ＆ Clinical Pharmacology,School of Pharmaceutical Sciences,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou 511436,Guangdong,China)

机构地区：[1]广州医科大学药学院分子靶标与临床药理学重点实验室广州医科大学附属第二医院,广东广州511436

出　　处：《合成材料老化与应用》2018年第5期106-109,共4页Synthetic Materials Aging and Application

基　　金：广东省自然科学基金项目(编号:2015A030310037);广东省医学科研基金项目(编号:A2017069);广州市教育局科研基金项目(编号:1201610085;1201430509;1201610202);广州医科大学科学科研基金项目(编号:2014C09)

摘　　要：商业化离子交换型微球栓塞剂仅能负载荷正电的药物,且本身不能被X射线、CT或MRI检测,在现有的影像学设备下不可视,不利于栓塞术中监控和术后复查。该文总结了离子交换型微球栓塞剂载药及可视化方面的研究报道,介绍了前沿最新进展以及在临床研究与应用中的现状,最后提出离子交换型微球栓塞剂在载药及可视化方面将来的发展方向。Commercial ion-exchange microsphere embolic agents can just load positively-charged drug molecules,and are not visible in the current imaging devices,which is not helpful for operation monitor and post-operation examinations. In this review,recent reports related todrug loading and visualization studies of ion-exchange microsphere embolic agents were summarized. Besides,the frontier research advances together with clinical research progress of ion-exchange microsphere embolic agents were also introduced. At last,this review proposed future development direction of this kind of embolic agents in terms of drug loading and visibility.

关 键 词：离子交换型微球栓塞剂 动脉栓塞 可视化 药物载体 

分 类 号：R972.6[医药卫生—药品]