膝骨关节炎患者病情严重程度与尿CTX-Ⅱ及尿COMP的相关研究  

Correlation between the Severity of Knee Osteoarthritis with Urinary Collagen Type Ⅱ C-telopeptide and Urinary Cartilage Oligomeric Matrix Protein

作　　者：颜世昌[1] 魏建军[1] 杨永江[1] 彭俊洋 陈晖[1] YAN Shichang;WEI Jianjun;YANG Yongjiang;PENG Junyang;CHEN Hui(Department of Orthopedics,the Affilicated BenQ Hospital of Nanjing Medical University,Nanjing 210019,China)

机构地区：[1]南京医科大学附属明基医院骨科,南京210019

出　　处：《医学综述》2018年第20期4123-4126,4132,共5页Medical Recapitulate

基　　金：南京市医学科技发展项目(YKK17250)

摘　　要：目的观察膝骨关节炎(KOA)患者尿Ⅱ型胶原C端肽(CTX-Ⅱ)及软骨寡聚基质蛋白(COMP)的表达变化,并探讨其与病情严重程度的相关性。方法选取2017年8月至2018年3月于南京医科大学附属明基医院被明确诊断为KOA的113例患者作为KOA组,Kellgren-Lawrence(K-L)分级:Ⅰ级27例,Ⅱ级34例,Ⅲ级27例,Ⅳ级25例。另外随机选取同期30名健康体检者作为对照组。通过酶联免疫吸附试验法检测所有受试者尿CTX-Ⅱ及COMP水平,并对检测结果进行分析、比较。结果 KOA组尿CTX-Ⅱ及COMP水平明显高于对照组(P <0. 05);KOA患者尿CTX-Ⅱ及COMP水平随K-L分级的增加而逐渐升高,且各K-L级别间尿CTX-Ⅱ及COMP水平比较差异有统计学意义(P <0. 05); KOA患者K-L分级与尿CTX-Ⅱ(r=0. 357,P=0. 002)及COMP(r=0. 206,P=0. 005)呈正相关。结论 KOA可引起尿CTX-Ⅱ及COMP水平升高,两者可作为KOA诊断及严重程度评估的参考标志物。Objective To observe the expression of urinary collagen type Ⅱ C-telopeptide （CTX-Ⅱ ） and cartilage oligomerie matrix protein（COMP） in patients with knee osteoarthritis（KOA） ,and explore their relevance to the severity of the disease. Methods A total of 113 patients with KOA diagnosed in the Affiliated BenQ Hospital of Nanjing Medical University from Aug. 2017 to Mar. 2018 were included as a KOA group. Depending on the Kellgren-Lawrence（K-L） classification, they were classified ： grade Ⅰ 27 cases, grade Ⅱ 34 cases, grade Ⅲ 27 cases, grade Ⅳ 25 cases. At the same time,30 healthy people during the same period were randomly chosen as a control group. The urinary CTX-Ⅱ and COMP in all subjects were detected by enzyme linked inmmnosorbent assay and the results were mlalyzed and compared. Results Levels of urinary CTX- Ⅱ and COMP in the KOA group were obviously higher than those in the control group （P 〈 0.05 ）. The levels of urinary CTX- Ⅱ and COMP in the KOA group increased gradually with the increase of K-L grade ,with statistically significant difference （ P 〈 0.05 ）. K-L grade in KOA patients was positively correlated with urinary- CTX-Ⅱ（ r = 0. 357, P = 0.002） and COMP（ r = 0. 206, P = 0. 005 ）. Conclusion KOA can cause elevated levels of urinary- CTX-Ⅱ and COMP, which can both be used as reference markers for the diagnosis and severity assessment of KOA.

关 键 词：膝骨关节炎 尿Ⅱ型胶原C端肽 尿软骨寡聚基质蛋白 

分 类 号：R684.3[医药卫生—骨科学] R274.9[医药卫生—外科学]