46项临床免疫检测项目餐前餐后检测结果的比较  

Comparison of Results of 46 Clinical Immunology Tests before and after Meal

作　　者：李秀玉[1] 王培昌[1] 刘畅[1] 傅庆华 宿占军 LI Xiuyu;FANG Peichang;LIU Chang;FU Qinghua;SU Zhanjun(Department of Clinical Laboratory,Xuanwu Hospital,Captital Medcial University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院检验科,北京100053

出　　处：《医学综述》2018年第20期4142-4146,4151,共6页Medical Recapitulate

摘　　要：目的探讨"全时段采血"实施背景下餐后采血对临床免疫检测项目的影响。方法选取2017年4月于首都医科大学宣武医院体检的健康志愿者30名,分别于餐前和餐后2 h、4 h采集静脉血检测肿瘤标志物12项、感染术前8项(乙型肝炎表面抗原、乙型肝炎表面抗体等)、特定蛋白8项、甲状腺功能及抗体8项及其他10项化学发光检测项目共46项临床免疫指标,分析其差异。结果餐前和餐后神经元特异性烯醇化酶水平比较差异有统计学意义(P <0. 05),餐后4 h低于餐前和餐后2 h(P <0. 05)。餐前和餐后细胞角蛋白19片段水平比较差异有统计学意义(P <0. 05),餐后2 h、餐后4 h低于餐前(P <0. 05)。餐前和餐后胰岛素、C肽水平比较差异有统计学意义(P <0. 05),餐后2 h、4 h的胰岛素、C肽高于餐前,且餐后2 h结果高于餐后4 h(P <0. 05)。其他临床免疫学指标的餐前和餐后检测结果差异无统计学意义(P> 0. 05)。结论餐后4 h内采血检测临床免疫指标,大部分检测数据均能满足临床诊治需求,故"全时段采血"值得在更多类型的患者和更大范围时间内进行实践。Objective To explore the effect of postprandial learning on clinical immunology test items in the context of ＂full-time blood collection＂. Methods A total of 30 healthy volunteers who had physical examination in Xuanwu Hospital, Captital Medcial University in April 2017 were selected. Altogether 46 clinical inmmnologic indexes 2 h before and 4 h after meal were selected including 12 tumor markers ,8 preoperative ilffeetion indexes（ hepatitis B surface antigen, hepatitis B surface antibody, etc. ） , specific protein 8 items, thyroid function and antibody 8 items and other 10 ehemilumineseenee detection items, and the differences between before and after meal were analyzed. Results The differences in the levels of neuron-specific enolase before and after meal were statistically significant（ P 〈 0.05 ） , and the results of 4 h after meal were lower than that before meal and 2 h after meal（ P 〈 0.05 ）. The differences in the levels of eytokeratin 19 fragments before and after meal were statistically significant（ P 〈 0.05 ） , and 2 h and 4 h after meal were lower than before meal （P 〈 0.05 ）. There were statistically significant differences in insulin and C-peptide levels before and after meal （ P 〈 0.05 ）. Insulin and C-peptide levels at 2 h and 4 h after meal were higher than those before meal, and results at 2 h after meal were higher than those at 4 h after meal（ P 〈 0.05 ）. Other clinical immunologic indexes had no statistically significant differences before and after meal. Conclusion Most of the within 4 h postprandial blood immune indexes testing data can meet the need of the clinical diagnosis and treatment, therefore,＂ full-time blood collection＂ is worthy to be practiced in more types of patients and a larger time scope.

关 键 词：全时段采血 临床免疫 变异 

分 类 号：R446.62[医药卫生—诊断学]