细胞支架联合成纤维细胞生长因子修复手指急性创伤性软组织缺损  

Combined treatment using cell scaffold and human fibroblast growth factor for small soft tissue defects of digits caused by trauma

作　　者：张治金 曾林如 杨军 侯桥 刘龙飞 Zhang Zhijin;Zeng Linru;Yang Jun;Hou Qiao;Liu Longfei(Xiaoshan Hospital of Traditional Chinese Medicine,Hangzhou 311201,China)

机构地区：[1]杭州萧山中医院手外科,311201

出　　处：《中华整形外科杂志》2018年第9期729-732,共4页Chinese Journal of Plastic Surgery

摘　　要：目的 探讨细胞支架联合成纤维细胞生长因子修复手指急性创伤性软组织缺损的治疗效果.方法 2012年5月至2016年9月,对20例手指较小面积软组织缺损患者,应用细胞支架联合重组人碱性成纤维细胞生长因子进行修复.平均缺损面积2.5 cm2.创面清创,应用人工真皮修复.每隔2-3d创口换药并外用成纤维细胞生长因子.术后3-4周拆除细胞支架.结果 本组20例,随访2- 24个月,未见创面复发,外观满意,无明显增生性瘢痕.指间关节伸屈活动无明显障碍.结论 细胞支架联合成纤维细胞生长因子修复创面,方法简便、创面愈合质量高,为创面的修复提供了新选择.Objective To assess the effect of combined treatment using cell scaffold and human fibroblast growth factor for small soft tissue defects of digits caused by trauma.Methods From May 2012 to September 2016,twenty cases of small soft tissue defect of digits were repaired with cell scaffold combined with recombinant human basic fibroblast growth factor.The average defect area was 2.5 cm2.Wounds were debrided and repaired with artificial dermis.Every 2 or 3 days the dressings were changed and the wounds were treated externally with fibroblast growth factor until cell scaffolds have been removed 3-4 weeks after surgery.Results The group of 20 cases was followed up for 2-24 months.Wounds were healed with satisfactory appearance and no recurrence of wound or obvious hypertrophic scar was observed.No obvious functional problem was found in interphalangeal motion.Conclusions The method of repairing wound with cell scaffold combined with human fibroblast growth factor is simple and it result in healing of wounds with high quality.It provides a new choice for repairing wound in digits.

关 键 词：细胞支架 成纤维细胞生长因子 手指 缺损 

分 类 号：R658.2[医药卫生—外科学]