原发性干燥综合征合并静脉血栓患者的临床特点  

Clinical features of patients with primary Sjogren's syndrome complicated with venous thrombosis Zhang

作　　者：张永锋[1] 路跃武[1] Yongfeng;Lu Yuewu(Department of Rheumatology and Immunology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院风湿免疫科,100020

出　　处：《中华医学杂志》2018年第39期3197-3199,共3页National Medical Journal of China

摘　　要：目的分析原发性干燥综合征（pSS）合并静脉血栓病例的临床特点，提高对该病的认识。方法北京朝阳医院2013年1月至2017年10月资料完整的pSS合并静脉血栓病例的临床和实验室特点。16例中女14例，男2例，年龄45～71岁。结果单侧小腿肌间静脉血栓6例，双侧肌间静脉血栓1例，右侧胫后静脉血栓1例，单侧腘静脉血栓2例，双下肢静脉血栓合并肺栓塞2例，颈静脉血栓2例，单大隐静脉血栓2例。12例患者以干燥症状起病，4例患者以肺部症状起病。16例患者抗心磷脂抗体、狼疮抗凝物均为阴性。抗SSA 52 000抗体、抗SSA 60 000抗体阳性例数分别12例。16例患者均伴有间质肺疾病。结论pSS患者具有潜在静脉血栓高风险，尤其是合并间质肺疾病和抗SSA抗体阳性患者，更应提高对pSS患者静脉血栓的警惕。ObjectiveTo analyze the clinical characteristics of primary Sj？gren′s syndrome （pSS） with venous system thrombosis （VT）, and to improve the understanding of the disease.MethodsThe clinical and laboratory characteristics of 16 cases of pSS with VT were analyzed retrospectively.ResultsAmong 16 cases, 12 cases was women, 2 case was men, age between 45 and 71.There were 14 cases of lower extremity VT, 2 case of jugular vein thrombosis.Twelve patients admitted with dry symptoms and 4 patients with pulmonary symptoms.Antiphospholipid antibodies were negative.The positive cases of anti-SSA 52 000 and anti-SSA 60 000 were 12 cases respectively.Sixteen cases had interstitial lung diseases.ConclusionpSS are potential VT high risk, especially in patients with interstitial lung disease and anti-SSA positive.We should improve the VT vigilance of pSS patients.

关 键 词：原发性干燥综合征 静脉血栓形成 抗磷脂抗体 

分 类 号：R593.2[医药卫生—内科学]