塞来昔布热熔压敏胶的制备及质量评价  

Preparation and Quality Evaluation of Celecoxib Hotmelt Pressure Sensitive Adhesive

作　　者：崔颖[1] 邓莉[1] Cui Ying;Deng Li(Affiliated Tianyou Hospital of Wuhan University of Science and Technology,Wuhan 430064,China)

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《中国药师》2018年第10期1857-1860,共4页China Pharmacist

摘　　要：目的:制备塞来昔布热熔压敏胶,对其质量进行考察。方法:采用苯乙烯-异戊二烯-苯乙烯(SIS)嵌段共聚物为主要辅料制备塞来昔布热熔压敏胶,以初黏力、剥离强度、熔融温度和体外经皮渗透试验对其进行质量评价。结果:塞来昔布热熔压敏胶的初黏力(17. 79±0. 25) N、剥离强度(2. 81±0. 49) N·cm^(-2)、熔融温度(90. 8±1. 9)℃,24 h累积渗透量为(18. 77±1. 51) mg·cm^(-2)。结论:热熔压敏胶适合于塞来昔布透皮给药系统。Objective： To prepare celecoxib hotmelt pressure sensitive adhesive（ HMPSA）,and investigate the quality. Methods：Celecoxib HMPSA was prepared using styrene-isoprene-styrene triblock copolymer（ SIS） as the chief material,and the quality of HMPSA was inspected with stickiness,peel strength,melt temperature and percutaneous permeation rate in vitro as the indices. Results：The stickiness of celecoxib HMPSA was（ 17. 79 ± 0. 25） N,the peel strength was（ 2. 81 ± 0. 49） N·cm^-2,the melt temperature was 90. 8 ± 1. 9℃,and the percutaneous permeation rate in 24 h was（ 18. 77 ± 1. 51） mg·cm^-2. Conclusion： The HMPSA is suitable for the preparation of TDDS of celecoxib.

关 键 词：热熔压敏胶 塞来昔布 经皮渗透 质量评价 

分 类 号：R944.9[医药卫生—药剂学]