气相色谱法同时测定心可宁胶囊中樟脑和冰片的含量  

Simultaneous Determination of Borneol and Camphor in Xingkening Capsules by GC

作　　者：罗时 邱婧 李瑞莲 潘震宇 Luo Shi;Qiu Jing;Li Ruilian;Pan Zhenyu(Hunan Institute for Drug Control,Changsha 410001,China)

机构地区：[1]湖南省药品检验研究院,长沙410001

出　　处：《中国药师》2018年第10期1881-1883,共3页China Pharmacist

摘　　要：目的:建立气相色谱法同时测定心可宁胶囊中樟脑和冰片含量的方法。方法:采用聚乙二醇20000(PEG-20M)为固定相的毛细管柱(30 m×0. 53 mm,1μm)为色谱柱,载气为氮气,流速为3. 0 ml·min^(-1),进样口温度为200℃,氢离子火焰检测器温度为210℃,柱温为140℃,分流比为1∶1。结果:龙脑在13. 25～1 325. 19μg·ml^(-1)(r=0. 999 9)浓度范围内线性关系良好,平均加样回收率为100. 22%,RSD为0. 92%(n=6);樟脑在1. 029～16. 464μg·ml^(-1)(r=0. 997 5)浓度范围内线性关系良好,平均加样回收率为98. 89%,RSD为2. 78%(n=6)。结论:该方法简便、准确、可靠,可用于心可宁胶囊的质量控制。Objective： To establish a GC method for the determination of borneol and camphor in Xingkening capsules. Methods：A capillary column using polyethylene glycol 20000（ PEG-20 M） as the stationary phase（ 30 m × 0. 53 mm,1 μm） was employed. The flow rate of carries gas（ N_2） was 3. 0 ml·min^-1. The inlet temperature was 200℃,the temperature of flame ionization detector was 210℃,the column temperature was 140℃,and the split ratio was 1 ∶ 1. Results： The linear range of borneol was 13. 25-1 325. 19μg·ml^-1（ r = 0. 999 9）,and the average recovery was 100. 22% with the RSD of 0. 92%（ n = 6）. The linear range of camphor was1. 029-16. 464 μg·ml^-1（ r = 0. 997 5）,and the average recovery was 98. 89% with the RSD of 2. 78%（ n = 6）. Conclusion： The method is simple,accurate and reliable,which can be used for the quality control of borneol and camphor in Xingkening capsules.

关 键 词：心可宁胶囊 樟脑 冰片 气相色谱法 含量测定 

分 类 号：R927.2[医药卫生—药学]