植物PLC-DGK/PA途径介导的渗透胁迫应答反应  

Plant PLC-DGK/PA Pathway Mediated Osmotic Stress Response

作　　者：贾哓玮 贾羊羊 司旭阳 潘延云 Jia Xiaowei;Jia Yangyang;Si Xuyang;Pan Yanyun(Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology College of Life,Hebei Agricola University,Baoding 071000,China)

机构地区：[1]河北农业大学生命科学学院河北省植物生理与分子病理学重点实验室,保定071000

出　　处：《中国细胞生物学学报》2018年第9期1564-1572,共9页Chinese Journal of Cell Biology

基　　金：河北省自然科学基金项目(批准号:2017204095);河北省高等学校科学技术研究项目(批准号:ZD2017039)资助的课题~~

摘　　要：肌醇磷脂依赖的磷脂酶C(PLC)是经典肌醇磷脂信号系统的重要组分,它分解二磷酸磷脂酰肌醇分子(PIP2)产生双信使IP3和DAG分子。动物细胞中DAG激活蛋白激酶C(PKC)参与调节多种细胞功能。植物基因组中缺乏PKC的同源序列,DAG被二酰甘油激酶(DGK)进一步磷酸化形成磷脂酸(PA),形成新的植物特有的第二信使分子。酶蛋白PLC和DGK及其作用的底物和产物形成植物特色的信号途径,该信号途径在植物对非生物和生物胁迫的反应中发挥重要作用。该文从蛋白信号分子的表达特征和脂质信号分子的含量变化等两个方面综述了植物特色的肌醇信号途径PLC-DGK/PA在应答渗透胁迫反应中的作用。除了PLC-DG活性外,PA也可由磷脂酶D(PLD)产生。该文还对两种途径产生的PA进行了讨论。Phosphoinositide（PI）-specific phospholipase C（PLC） is one of the important component of the canonical PI signaling system. Stimulation activates PLC, which hydrolyses phosphatidylinositol 4,5-bisphosphate（PIP2） into two second messengers： inositol 1,4,5-trisphosphate（IP3） and diacylglycerol（DAG）. DAG activated protein kinase C（PKC） by which regulate a wide variety of cellular functions in animals. Plant genomes lack homologues of the PKC. Instead, plants utilize the phosphatidic acid（PA）, phosphorylation products of DAG by diacylglycerol kinase（DGK）, as a new plant-specific second messengers. These enzymes and their reaction substrates and products play important and multifaceted roles in plant response to abiotic and biotic stresses. In this paper, we reviewed the role of plant PLC-DGK/PA pathway in response to osmotic stress based on the expression characteristics of PLC and DGK and the changes of lipid signal molecules. In addition to PLC-DG activity, PA can also be produced by phospholipase D（PLD）, and the actions of common and distinguishable among the different pathways will also be discussed.

关 键 词：肌醇磷脂依赖的磷脂酶C 二酰甘油激酶 磷脂酸 渗透胁迫 

分 类 号：Q945.78[生物学—植物学]