三维打印技术在皮肤组织修复上的应用  

Utilization of three-dimensional printing technology for repairing skin tissue

作　　者：林越威 敖宁建[1,2] LAM Yuet-wai;AO Ningjian(Department of Biomedical Engineering,Jinan University,Guangzhou 510632,P.R.China;Key Laboratory of Biomaterials,Guangdong Provincial Department of Education,Guangzhou 510632,P.R.China)

机构地区：[1]暨南大学生命科学技术学院生物医学工程系,广州510632 [2]广东省教育厅生物材料重点实验室,广州510632

出　　处：《生物医学工程学杂志》2018年第5期805-810,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(20976068/B060805);广东省科技厅科技计划项目(2017A020211006)

摘　　要：三维打印是一种低成本、高效益的生产方法,有助于改善目前皮肤修复材料产业成本高昂、利润放缓的趋势,并开发出性能更优秀的产品。常用于皮肤修复材料制备中的三维打印技术有熔融沉积成型技术和三维生物打印技术:其中熔融沉积成型技术具有设备简单轻巧的优点,但材料选择不足;三维生物打印技术可供选择的材料较多,但设备笨重且昂贵。近年对两种技术的研究均集中于材料的开发和应用上。本文详细介绍了熔融沉积成型技术和三维生物打印技术的原理、在伤口敷料和组织工程皮肤生产上的研究进展,以及三维打印在皮肤组织修复上的未来发展,包括容貌修复和仿生组织工程皮肤的研究,并对三维打印技术应用在皮肤组织修复领域的发展进行了展望。Three-dimensional（3D） printing is a low-cost,high-efficiency production method,which can reduce the current cost and increase the profitability of skin repair material industry nowadays,and develop products with better performance.The 3D printing technology commonly used in the preparation of skin repair materials includes fused deposition molding technology and 3D bioprinting technology.Fused deposition molding technology has the advantages of simple and light equipment,but insufficient material selection.3D bioprinting technology has more materials to choose from,but the equipment is cumbersome and expensive.In recent years,research on both technologies has focused on the development and application of materials.This article details the principles of fused deposition modeling and 3D bioprinting,research advances in wound dressings and tissue engineering skin production,and future developments in 3D printing on skin tissue repair,including cosmetic restoration and biomimetic tissue engineering.Also,this review prospects the development of 3D printing technology in skin tissue repairment.

关 键 词：三维打印 伤口敷料 组织工程皮肤 熔融沉积成型 三维生物打印 

分 类 号：R318[医药卫生—生物医学工程] TP391.73[医药卫生—基础医学]