乙酰胆碱α4β2型受体与抑郁症  

The research advance on the α4β2 acetylcholine receptor and depression

作　　者：于子茹 杜冠华[1] YU Zi-ru;DU Guan-hua(Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《药学学报》2018年第10期1583-1590,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81603100);国家重点研发计划资助项目(2016YFC1000905);中国医学科学院医学与健康科技创新工程(2017-I2M-1-010)

摘　　要：抑郁症作为情感性神经疾病是目前世界上最易致残的疾病之一,且有着很高的自杀率。目前临床应用的一线药物选择性5-HT再摄取抑制剂一直具有极大的局限性。抑郁症发病机制复杂,胆碱能假说近年来受到了关注。已有大量临床及临床前研究表明,烟碱型乙酰胆碱受体的拮抗剂和部分激动剂对于抗抑郁治疗具有显著作用,可以改善患者海马功能、影响腹侧中脑和腹侧被盖区奖赏与焦虑系统并调节杏仁核应激系统,从而达到改善情绪、缓解抑郁症的作用。目前围绕着胆碱能系统与抑郁症的关系仍在进行着大量研究,该文对胆碱受体α4β2亚型与抑郁症的关系及其机制进行了综述,供抗抑郁新药研发人员参考。Depression is currently the most popular disease in the world with a high suicide rate. Selective 5-HT reuptake inhibitors have been used as first-line drugs in clinics, but the therapeutic effect is greatly limited. The pathogenesis of depression is complicated, meanwhile the cholinergic hypothesis has received more and more attention. A large number of clinical and preclinical studies have shown that antagonists and partial agonists acting on nicotinic acetylcholine receptors have a significant effect on antidepressant therapy, which can improve the hippocampus recognizes, influence rewards and anxiety systems controlled by the ventral midbrain and ventral tegmental area, and regulate the amygdala pressure system, thereby improving mood and relieving depression. At present, the relationship between the cholinergic system and depression is still undergoing a lot of research. In this article, the relationship between α4β2 nicotinic acetylcholine receptor（nAChRs） and depression is reviewed to provide a reference for study of new anti-depression drugs.

关 键 词：α4β2烟碱型乙酰胆碱受体 胆碱能假说 抑郁症 情感障碍 

分 类 号：R964[医药卫生—药理学]