纳米药物递送系统的细胞药代动力学研究进展  

Research progress in cellular pharmacokinetics of nano-drug delivery systems

作　　者：王兴 王瑶琪 张强[1] 易崇勤 王学清[1] WANG Xing;WANG Yao-qi;ZHANG Qiang;YI Chong-qin;WANG Xue-qing(School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Founder Medical Research Institute Co.,Ltd.,Beijing 102206,China)

机构地区：[1]北京大学药学院,北京100191 [2]方正医药研究院有限公司,北京102206

出　　处：《药学学报》2018年第10期1620-1629,共10页Acta Pharmaceutica Sinica

基　　金：北京市自然科学基金资助项目(7162108)

摘　　要：纳米药物递送系统(nano-DDS)具有缓控释、靶向等诸多优点,是新型药物递送系统研究的热点。传统宏观的药代动力学有时难以真实有效地预测体内药物的药效,迫切需要将传统的药代动力学研究拓展到细胞/亚细胞水平,进行细胞药代动力学研究。对nano-DDS细胞药代动力学的研究有助于更全面地阐明其在细胞中的作用机制,指导nano-DDS的设计与开发。本文主要总结了nano-DDS细胞药代动力学的研究内容和研究方法,为nano-DDS的前期设计提供重要的参考依据。Nano-drug delivery systems（nano-DDS） are the hotspots of new drug delivery systems, which have many advantages, such as sustained and controlled release, targeting delivery. Traditional pharmacokinetics are difficult to predict the efficacy of drugs in vivo sometimes. It is urgently needed to extend the traditional pharmacokinetics studies to the cell/subcellular level and perform cell pharmacokinetic studies. The study on the pharmacokinetics of nano-DDS helps us to elucidate the mechanism of the actions of them in cells and guides us to design and develop nano-DDS more reasonably. This article summarizes the research content and methods on the cellular pharmacokinetics of nano-DDS, in order to provide an important reference for the early stage design of nano-DDS.

关 键 词：纳米药物递送系统 细胞药代动力学 分析方法 

分 类 号：R943[医药卫生—药剂学]