基于线粒体研究论脾虚与脏腑疾病的相关性  

Correlation of Spleen Deficiency and Viscera Diseases Based on the Research of Mitochondria

作　　者：杨晔 刘悦 张帆 孙宇衡 王钰 张哲 杨关林 YANG Ye;LIU Yue;ZHANG Fan;SUN Yuheng;WANG Yu;ZHANG Zhe;YANG Guanlin(Liaoning University of Traditional Chinese Medicine,Shenyang,110032;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine)

机构地区：[1]辽宁中医药大学研究生学院 [2]辽宁中医药大学附属医院

出　　处：《中医杂志》2018年第20期1742-1746,共5页Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划("973"计划)(2013CB531704);国家自然科学基金(81703970);辽宁省教育厅科学技术研究项目(L201625);辽宁中医药大学中医脏象理论及应用国家教育部重点实验室开放基金(zyzx1607)

摘　　要：脾主运化,为气血生化之源,仓廪之官,是人体的后天之本。细胞器线粒体几乎存在于所有需氧真核细胞内,其作为"细胞的动力站"而为机体的物质代谢提供能量,被称作"能量转化的中心站"和"三磷酸腺苷(ATP)的生产基地"。由此可见,脾与细胞器线粒体在人体功能方面异曲同工。结合有关脾虚导致人体各脏腑疾病与线粒体结构功能变化相关性的动物实验与临床研究,探讨中医"脾主运化"与线粒体形态结构及氧化磷酸化的相关性,从而揭示中医脾虚导致全身各脏腑疾病的线粒体结构功能变化机制,为今后脾虚证的诊治提供现代医学理论支撑。The spleen governs transportation and transformation in body. Traditional Chinese medicine（ TCM）believes that the spleen is ＂the source of generating qi and blood＂,＂barn organs＂and ＂the foundation of acquired constitution＂. As＂the power station of cells＂,the organelle of mitochondrion provides energy for the material metabolism of human body,almost existing in all aerobic eukaryotic cells. It is known as ＂the center of energy transformation＂and ＂the production base of adenosine triphosphate（ ATP） ＂. Thus it can be seen that spleen and mitochondrion of cells are similar in human function. Combining the animal experiment and clinical research on the relationship between the visceral spleen caused by the spleen deficiency and the changes of mitochondrial structure and function,this paper discussed the correlation between ＂spleen transport＂in TCM and mitochondrial morphological structure and oxidative phosphorylation,and explored the mitochondrial mechanism of various viscera diseases caused by spleen deficiency in TCM and mitochondrial structure and function changes,and provided theoretical support of modern medicine and prospect of clinical application to the diagnosis and treatment of spleen deficiency syndrome for the future.

关 键 词：脾虚 线粒体 心病 肝病 胃肠疾病 骨骼肌 脑病 

分 类 号：R256[医药卫生—中医内科学]