Cabergoline治疗女性高泌乳素血症患者的临床效果  

Clinical efficacy of Cabergoline in the treatment of female hyperprolactinemia

作　　者：苏雅琴[1] 张宁宁[1] 梁小青[1] 张少静[1] 魏永志[1] SU Yaqin;ZHANG Ningning;LIANG Xiaoqing;ZHANG Shaojing;WEI Yongzhi(Department of Gynaecology,the First Hospital of Shijiazhuang City,Hebei Province,Shijiazhuang 050011,China)

机构地区：[1]河北省石家庄市第一医院妇科,河北石家庄050011

出　　处：《中国医药导报》2018年第29期79-81,87,共4页China Medical Herald

基　　金：河北省石家庄市科学技术研究与发展指导计划(151460723)

摘　　要：目的探讨Cabergoline在治疗女性高泌乳素血症患者月经异常与泌乳等方面的应用价值。方法选取石家庄市第一医院妇科2014年6月～2017年6月诊治的高泌乳素血症患者作为研究对象,依据随机数字表法分组,观察组(n=45)采用Cabergoline治疗,对照组(n=45)采用溴隐亭治疗。记录两组治疗后血清泌乳素值变化情况、临床症状疗效、药物不良反应发生率以及耐药情况。结果观察组用药后2、3个月的血清泌乳素水平均低于对照组(P <0.05);观察组月经异常的治疗有效率高于对照组(P <0.05);两组溢乳和视力下降、头痛等其他症状的治疗有效率比较差异无统计学意义(P> 0.05);观察组恶心呕吐、低血压和精神症状不良反应发生率均低于对照组(P <0.05);两组耐药率比较,差异无统计学意义(P> 0.05)。结论与溴隐亭比较,Cabergoline治疗女性高泌乳素血症患者降泌乳素效果更好、月经异常症状改善也更明显,同时药物不良反应发生率更低。Objective To explore the application value of Cabergoline in the treatment of abnormal menstruation and galactorrhea in women with hyperprolactinemia. Methods Patients with hyperprolactinemia treated from June 2014 to June 2017 in the First Hospital of Shijiazhuang City were selected. They were divided into two groups according to the random number table. The observation group （n = 45） was treated with Cabergoline, while the control group （n = 45） was treated with Bromocriptine. Before and after treatment, the changes of the serum prolactin value, the clinical symp- tom effect, the incidence of drug adverse reaction and the drug resistance of the two groups were recorded. Results The serum prolactin values of observation group at 2 and 3 months after treatment were lower than those of control group （P 〈 0.05）. The effective rate of abnormal menstruation in observation group was higher than that of control group （/9 〈 0.05）. There was no statistically significant difference in treatment efficiency between the two groups for galactorrhea, visual impairment, headache and other symptoms （P 〉 0.05）. The incidence of adverse reaction such as nausea, vomiting, hy- potension, and mental symptoms in observation group were lower than those in control group （/9 〈 0.05）. There was no statistically significant difference in drug resistance rate between two groups （/9 〉 0.05）. Conclusion Compared with the Bromocriptine, Cabergoline has better effect on reducing prolactin value, improvement of abnormal menstruation and lower incidence of drug adverse reactions in women with hyperprolactinemia.

关 键 词：CABERGOLINE 高泌乳素血症 溴隐亭 月经异常 

分 类 号：R711.6[医药卫生—妇产科学]