急性颅脑伤患者血清内源性类洋地黄物质含量变化观察  

Serum Concentration Changes of an Endogenous Digoxin-Like Substance in 34 Patients with Acute Craniocerebral Injuries

作　　者：徐有奇[1] 袁立功[1] 江虹[1] 孙晓川[2] 郑履平[2] 

机构地区：[1]第三军医大学大坪医院特检科 [2]重庆医科大学附属一院脑外科

出　　处：《中华创伤杂志》1991年第1期5-7,共3页Chinese Journal of Trauma

摘　　要：本文测定了34例急性颅脑伤(ACI)患者和正常组50例的血清内源性类洋地黄物质(EDLS)和垂体泌乳素(PRL)含量。结果ACI患者血清EDLS和PRL含量高于对照组(P<0.001)。EDLS含量与意识状态密切相关。EDLS和PRL含量高者提示下丘脑和垂体损伤。ACI患者EDLS和PRL升高的机理我们分析有两种:其一是损伤时机体的应激反应;其二是脑下部一垂体系统损害。Serum concentrations of endogenous digoxin-like substance (EDLS) and prolactin (PRL) in 34 patients with acute craniocerearal in jules (ACI) were determined by radioimmunoassay. The result showed that serum EDLS and PRL in these patients were significantly higher than those in controt group (p<0.001). A good correlation was found between the serum of EDLS and duration of coma. The remarkable increase of serum EDLS and PRL suggests serious damage of hypothalamus-pituitary system. It is quite possible that the mechanism of the increase of serum EDLS and PRL concentration caused by ACI is related to stress reaction and damage to hypothalamus-pituitary axis.

关 键 词：脑损伤 EDLS 

分 类 号：R651.150.2[医药卫生—外科学]