阿托伐他汀钙联合阿司匹林对颈动脉粥样硬化患者颈部斑块的影响  

Effects of Atorvastatin Calcium Combined with Aspirin on Cervical Plaque in Patients with Carotid Atherosclerosis

作　　者：熊小平[1] 熊细艳 龚姝芸 熊武[2] XIONG Xiaoping;XIONG Xiyan;GONG Shuyun;XIONG Wu(Dept.of Medical Laboratory,Jiangxi Anyi County People＇s Hospital,Jiangxi Anyi 330500,China;Dept.of Neurology,Jiangxi Anyi County People＇s Hospital,Jiangxi Anyi 330500,China)

机构地区：[1]江西省安义县人民医院医技科,江西安义330500 [2]江西省安义县人民医院神经内科,江西安义330500

出　　处：《中国医院用药评价与分析》2018年第8期1063-1065,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨阿托伐他汀钙联合阿司匹林对颈动脉粥样硬化患者颈部斑块的影响。方法:选取2016年1月至2017年9月江西省安义县人民医院收治的颈动脉粥样硬化患者68例,以随机数字表法分为观察组和对照组,每组34例。两组患者均给予基础治疗;在此基础上,对照组患者给予阿司匹林肠溶片,观察组患者在对照组的基础上加用阿托伐他汀钙片。两组患者均连续用药6个月。比较两组患者治疗前后颈动脉粥样硬化斑块面积、颈动脉内膜中层厚度(IMT)、脑循环动力学参数[特性阻抗(Zc)、平均血流量(Qmean)、平均血流速(Vmean)及外周阻力(R)]及外周血血脂水平[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)]。结果:治疗后,两组患者颈动脉粥样硬化斑块面积、IMT明显小于治疗前,且观察组患者明显小于对照组;两组患者Zc、R水平明显低于治疗前,且观察组患者明显低于对照组;两组患者Qmean、Vmean明显高于治疗前,且观察组患者明显高于对照组;观察组患者TG、TC、HDL-C及LDL-C水平和对照组患者TC水平均较治疗前明显改善,且观察组患者TG、TC及LDL-C水平明显低于对照组,HDL-C水平明显高于对照组,上述差异均有统计学意义(P<0.05)。结论:阿托伐他汀钙联合阿司匹林可有效调节颈动脉粥样硬化患者的血脂代谢,稳定颈动脉粥样硬化斑块,改善患者脑循环动力学参数。OBJECTIVE： To probe into the effects of atorvastatin calcium combined with aspirin on cervical plaque in patients with carotid atherosclerosis. METHODS： 68 patients with carotid atherosclerosis admitted into Jiangxi Anyi County People＇s Hospital from Jan. 2016 to Sept. 2017 were extracted to be divided into observation group and control group via the random number table,with 34 cases in each. Two groups were given basic treatment,on this basis,the control group was treated with Aspirin enteric-coated tablets, and the observation group additionally received Atorvastatin calcium tablets based on the control group. Both groups were continuously treated for 6 months. The carotid atherosclerotic plaque area,carotid intima-media thickness（ IMT）,cerebral circulation dynamics parameters[characteristic impedance（ Zc）,mean blood flow（ Qmean）,mean blood flow rate（ Vmean）,and peripheral resistance（ R） ],peripheral blood lipids [triacylglycerol（ TG）,total cholesterol（ TC）,high density lipoprotein cholesterol（ HDL-C） and low density lipoprotein cholesterol（ LDL-C） ]levels of two groups were were compared before and after treatment. RESULTS： After treatment,the carotid atherosclerotic plaque area and IMT of two groups significantly reduced compared with before treatment,and the observation group was smaller than the control group; the level of Zc and R of two groups significantly lower than before treatment,and the observation group was lower than the control group;the Qmean and Vmean were significantly higher than before treatment,and the observation group was higher than the control group; the levels of TG,TC,HDL-C and LDL-C in observation group and the TC level in control group were significantly improved compared with those before treatment,and the levels of TG,TC and LDL-C in observation group were significantly lower than those in control group,and the HDL-C level was significantly higher than that in control group; with statistically significant differences（ P〈0. 05）. CON

关 键 词：阿托伐他汀钙 阿司匹林 颈动脉粥样硬化 斑块 脑循环动力学 脂代谢 

分 类 号：R972[医药卫生—药品]