氨甲环酸对减少同期双侧全髋关节置换术围术期出血的疗效观察  

Observation on Efficacy of Tranexamic Acid in Reducing Perioperative Hemorrhage in Simultaneous Bilateral Total Hip Arthroplasty

作　　者：郭家庆 孙永红 GUO Jiaqing;SUN Yonghong(Orthopedic Surgery,Hubei Gucheng People＇s Hospital,Hubei Gucheng 441700,China)

机构地区：[1]湖北省谷城县人民医院骨外二科,湖北谷城441700

出　　处：《中国医院用药评价与分析》2018年第8期1066-1067,1069,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨氨甲环酸对减少同期双侧全髋关节置换术围术期出血的疗效。方法:回顾性选取2014年8月至2017年8月湖北省谷城县人民医院收治的拟行同期双侧全髋关节置换术患者80例作为研究对象,根据是否应用氨甲环酸分为观察组和对照组,每组40例。观察组患者每侧手术切皮前均应用氨甲环酸,而对照组患者不应用。观察两组患者术后总失血量、输血率、血红蛋白(Hb)水平、红细胞比容(HCT)水平及术后并发症发生情况。结果:观察组患者平均术后总失血量为(1 542.25±225.65)ml,明显少于对照组的(1 995.25±285.68)ml,差异有统计学意义(P<0.05)。观察组患者的输血率为20%(8/40),明显低于对照组的50%(20/40),差异有统计学意义(P<0.05)。术后7 d,两组患者Hb、HCT水平明显低于术前,差异均有统计学意义(P<0.05),但组间比较的差异均无统计学意义(P>0.05)。两组患者术后并发症发生率的差异无统计学意义(P>0.05)。结论:氨甲环酸能有效减少同期双侧全髋关节置换术围术期患者的出血量。OBJECTIVE： To probe into the efficacy of tranexamic acid in reducing perioperative hemorrhage in simultaneous bilateral total hip arthroplasty. METHODS： 80 patients undergoing simultaneous bilateral total hip arthroplasty admitted into Hubei Gucheng People＇s Hospital from Aug. 2014 to Aug. 2017 were retrospectively selected and divided into observation group and control group according to whether tranexamic acid was applied or not,with 40 cases in each group. The observation group was given tranexamic acid before surgical incision,while the control group was not. The average total blood loss,blood transfusion rates,hemoglobin（ Hb）,hematocrit value（ HCT） and incidences of complications of two groups were observed. RESULTS： The average total blood loss of observation group was（ 1 542. 25 ± 225. 65） ml,which was significantly less than that of the control group [（ 1 995. 25 ± 285. 68） ml],with statistically significant difference（ P〈0. 05）. The blood transfusion rate of observation group was 20%（ 8/40）,which was significantly lower than that of the control group（ 50%,20/40）,with statistically significant difference（ P〈0. 05）. At 7 days after surgery,the Hb and HCT levels of both groups were significantly lower than those of before surgery,with statistically significant difference（ P〈0. 05）,while with no statistical significance in intra-group comparison（ P〈0. 05）. There was no statistical significance in difference of incidences of complications between two groups（ P〈0. 05）. CONCLUSIONS： Tranexamic acid can significantly reduce the perioperative hemorrhage in simultaneous bilateral total hip arthroplasty.

关 键 词：氨甲环酸 同期双侧全髋关节置换术 围术期出血 

分 类 号：R973.1[医药卫生—药品]