肝素联合头孢呋辛钠封管治疗用于血液透析患者中心静脉导管感染的疗效观察  

Observation on Efficacy of Heparin Combined with Cefuroxime Sodium in Treatment of Central Venous Catheter Infection in Hemodialysis Patients

作　　者：张丹 孙丽欣 张磊 修雪莲 张胜强 ZHANG Dan;SUN Lixin;ZHANG Lei;XIU Xuelian;ZHANG Shengqiang(Dept.of Hemodialysis,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Mudanjiang 157000,China;Dept.of Thoracic Surgery,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Mudanjiang 157000,China)

机构地区：[1]牡丹江医学院附属红旗医院血液透析室,黑龙江牡丹江157000 [2]牡丹江医学院附属红旗医院胸外科,黑龙江牡丹江157000

出　　处：《中国医院用药评价与分析》2018年第9期1215-1217,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨肝素联合头孢呋辛钠封管治疗用于血液透析患者中心静脉导管感染的临床疗效。方法:选取2015年1月至2017年1月牡丹江医学院附属红旗医院收治的中心静脉导管感染患者46例,以随机数字表法分为观察组和对照组,每组23例。对照组患者给予肝素联合庆大霉素封管治疗,观察组患者给予肝素联合头孢呋辛钠封管治疗。观察两组患者的临床疗效、并发症发生情况、置管时间及拔管比例。结果:观察组患者的总有效率为95.65%(22/23),明显高于对照组的73.91%(17/23),差异有统计学意义(P<0.05)。观察组患者并发症发生率为4.35%(1/23),明显低于对照组的26.09%(6/23),差异有统计学意义(P<0.05)。观察组患者平均置管时间为(62.28±11.09)min,明显长于对照组的(49.98±10.87)min;观察组患者的拔管比例为4.35%(1/23),明显低于对照组的26.09%(6/23),差异均有统计学意义(P<0.05)。结论:肝素联合头孢呋辛钠封管治疗用于血液透析患者中心静脉导管感染,能够减少感染的发生,有效延长导管留置时间,增强血液透析疗效。OBJECTIVE： To probe into the clinical efficacy of heparin combined with cefuroxime sodium in treatment of central venous catheter infection in hemodialysis patients. METHODS： 46 hemodialysis patients with central venous catheter infection admitted into Hongqi Hospital Affiliated to Mudanjiang Medical College from Jan.2015 to Jan. 2017 were extracted to be divided into observation group and control group via the random number table,with 23 cases in each. The control group was treated with heparin combined with gentamicin,while the observation group received heparin combined with cefuroxime sodium. The clinical efficacy,complications,placement time of tube and extubation ratio of two groups were observed. RESULTS： The total effective rate of observation group was 95. 65%（ 22/23）,significantly higher than that of control group（ 73. 91%,17/23）,with statistically significant difference（ P〈0. 05）. The incidence of complications of observation group was 4. 35%（ 1/23）,significantly lower than that of control group（ 26. 09%,6/23）,with statistically significant difference（ P〈0. 05）. The average placement time of tube in observation group was（ 62. 28 ± 11. 09） min,significantly longer than that in control group [（ 49. 98 ±10. 87） min]; the extubation ratio in observation group was 4. 35%（ 1/23）,significantly lower than that in control group（ 26. 09%,6/23）,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： Heparin combined with cefuroxime sodium in treatment of central venous catheter infection in hemodialysis patients can reduce the incidence of infection,prolong the placement time of tube and enhance the efficacy of hemodialysis.

关 键 词：肝素 头孢呋辛钠 封管治疗 血液透析患者 感染 

分 类 号：R978.1[医药卫生—药品]