五子五花汤加味治疗更年期综合征54例临床观察  

Clinical Observation of Modified Wuzi Wuhua Tang for 54 cases of Climacteric Syndrome

作　　者：王佳薇[1] 刘红丹 WANG Jiawei;LIU Hongdan

机构地区：[1]宁波市医疗中心李惠利医院中医科,浙江宁波315000 [2]宁波市李惠利东部医院中医科,浙江宁波315000

出　　处：《新中医》2018年第10期117-121,共5页New Chinese Medicine

摘　　要：目的:观察五子五花汤加味治疗脾肾两虚型更年期综合征患者的临床疗效。方法:108例患者随机分为治疗组和对照组,各54例。对照组采用雌孕激素结合周期性疗法治疗,治疗组采用五子五花汤加味治疗。观察2组临床疗效,检测血清游离三碘甲状腺原氨酸(FT_3)、促甲状腺激素(TSH)、雌二醇(E_2)、促黄体生成素(LH)水平。结果:治疗组总有效率为92.59%,显著高于对照组87.04%,差异有统计学意义(P <0.05)。治疗前,2组kupperman评分、血清FT_3、TSH、E_2、LH比较,差异均无统计学意义(P> 0.05)。治疗后,与治疗前比较,2组kupperman评分显著降低(P <0.05),血清FT_3、TSH、E_2含量显著升高(P <0.05);治疗组kupperman评分低于对照组(P <0.05),血清FT_3、TSH、E_2含量显著高于对照组(P <0.05)。结论:运用五子五花汤辨证治疗脾肾两虚型更年期综合征患者能有效缓解临床症状,也可一定程度上改善血清性激素和甲状腺相关激素水平的表达。Objective： To observe the clinical effect of modified Wuzi Wuhua tang for climacteric syndrome of spleen and kidney deficiency type. Methods： Divided 108 cases of patients into the treatment group and the control group randomly, 54 cases in each group. The control group was given estrogen and progesterone combined with periodical therapy for treatment,while the treatment group was given modified Wuzi Wuhua tang. Observed the clinical effect in the two groups, detected the changes of levels of free triiodothyronine（FT3）, thyroid stimulating hormone（TSH）, estradiol（E2） and luteinizing hormone（LH） in serum. Results： The total effective rate in the treatment group was 92.59%, obviously higher than that of 87.04% in the control group, the difference being significant（P〈0.05）. Before treatment,compared kupperman scores and levels of FT3,TSH,E2 and LH in serum in the two groups,there was no significance in differences（P〈0.05）. After treatment, kupperman scores in the two groups were significantly decreased when compared with those before treatment（P〈0.05）, and levels of FT3,TSH and E2 in serum were significantly increased when compared with those before treatment（P〈0.05）. The kupperman score in the treatment group was lower than that in the control group（P〈0.05）,and levels of FT3,TSH and E2 in serum in the treatment group were significantly higher than those in the control group（P〈0.05）. Conclusion：The therapy of modified Wuzi Wuhua tang for climacteric syndrome of spleen and kidney deficiency type based on syndrome differentiation can effectively improve the clinical symptoms and improve the expression of levels of sex hormone and thyroid related hormones in serum in a certain degree.

关 键 词：更年期综合征 五子五花汤 激素疗法 KUPPERMAN评分 游离三碘甲状腺原氨酸(FT3) 促甲状腺激素(TSH) 雌二醇(E2) 促黄体生成素(LH) 

分 类 号：R271.11[医药卫生—中医妇科学]