支气管颗粒细胞瘤临床及病理特点分析  

Analysis of clinical and pathological features of granular cell tumour of the bronchus

作　　者：聂姗[1] 徐秋芬[1] 姚志刚[1] 贾楠[1] NIE Shan;XU Qiufen;YAO Zhigang;JIA Nan(Department of Respiratory,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院呼吸内科,100050

出　　处：《心肺血管病杂志》2018年第9期835-839,共5页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:分析支气管颗粒细胞瘤(GCT)的临床特点,提高对GCT的认知、诊断、治疗能力。方法:回顾性分析我科收治的GCT患者,分析其临床特点,并通过临床资料检索文献。检索时间截止于2018年5月。结果:本例患者胸部CT见左主支气管内软组织团块影。行支气管镜镜下切除,术后病理结果示为GCT。共检索到27篇相关文献,42例支气管GCT患者,其中男女发病率一样,各占50%(21/42),发病年龄中位数为46岁,发病部位以右侧支气管为主,且右上叶为著(15/30)。病理存在显著特异性S-100(+)100%(35/35)。结论:支气管GCT十分罕见,患者在临床症状无特异性,病理可以确诊。该肿瘤绝大多为良性,彻底切除是其治疗的关键,彻底切除后一般无复发。Objective： To improve the ability of recognition,diagnosis and treatment of patients with Granular Cell Tumors（ GCT） of the Bronchus upon the analysis of its clinical features. Methods： We retrospectively analyzed the clinical data of the case of GCT of the Bronchus in our department,and searched the literature through clinical data till May 2018. Results： High-resolution CT lung showed a soft tissue mass in the left principal bronchus. A direct bronchoscopic biopsy was performed. The pathologic findings showed a granular cell tumor. A total 27 articles of literature have been retrieved,There are 42 patients with bronchial granular cell tumor,included 21 males（ 50%） 21 females（ 50%）,and the median age of the patients was 46 years old.The lesions are more prevalent in the right bronchus,especially in the right upper lobe（ 15/30） The immunohistochemical result with positive staining for antibodies to S100 100%（ 35/35）. Conclusion： Granular Cell Tumors of the Bronchus are exceedingly rare. The clinical manifestations were not specific and the diagnoses were made by pathology. Most GCT are benign. The complete resection is the key to treat GCT. This approach has result ed in a rare recurrence rate.

关 键 词：颗粒细胞瘤 支气管 病理特点 

分 类 号：R56[医药卫生—呼吸系统]