基于超微小ZnFe_2O_4纳米颗粒的新型T_1造影剂的制备及应用研究  

Preparation and Application of Ultrasmall ZnFe_2O_4 Nanoparticles-Based T_1 MRI Contrast Agent

作　　者：韩佳媚 梁国海 HAN Jiamei;LIANG Guohai(MOE Key Laboratory of Laser Life Science ＆ Institute of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,Guangdong,China)

机构地区：[1]华南师范大学生物光子学研究院激光生命科学研究所暨激光生命科学教育部重点实验室,广东广州510631

出　　处：《激光生物学报》2018年第4期313-319,共7页Acta Laser Biology Sinica

基　　金：国家自然科学基金(81630046);广东省博士科研启动项目纵向协同管理试点项目(3A0172)

摘　　要：非Gd型T_1造影剂的开发是近年来MRI造影剂的重要研究方向。本工作通过高温热分解法制备了粒径为(3. 02±0. 62) nm的掺杂Zn的氧化铁纳米颗粒(ZnFe_2O_4),其r1弛豫度为2. 5 L/(mmol·s),r2/r1比值为2. 2。合成方法简便、经济,容易实现大量制备。以生物相容性的PO-PEG分子对颗粒进行修饰,使颗粒相转移至水溶液中,可保持长期稳定分散。最后,以ZnFe_2O_4为造影剂,对小鼠肿瘤部位进行MR成像,获得～11%的信号增强。本研究工作显示ZnFe_2O_4@PO-PEG具备作为高安全性非钆型T_1造影剂并应用于实际MR造影成像的良好潜力。Non-gadolinium-based T1 contrast agents have attracted great interest in recent years. In this work,（3. 02 ± 0. 62） nm zinc-doped iron oxide nanoparticles（ZnFe2O4） with a high r1 relaxivity of 2. 5 L/（mmol·s） and low r2/r1 ratio of 2. 2 are synthesized using a one-pot thermal decomposition process. The synthetic procedure is simple,cost effective,and easy to scale up. The nanoparticles are modified with a biologically compatible ligand PO-PEG. Due to the hydrophilic polymer coating,the particles are highly dispersible and stable in aqueous solution. Finally,we applied the nanoparticles to in vivo magnetic resonance imaging and obtained a relative signal enhancement of 11% at the tumor region. This study revealed ZnFe2O4@ PO-PEG as a potential candidate for a non-gadolinium-based T1 contrast agent with extraordinary biosafety.

关 键 词：MRI T1造影剂 ZnFe2O4纳米颗粒 弛豫度 

分 类 号：TB383[一般工业技术—材料科学与工程]