甲硝唑阴道给药联合雌激素治疗萎缩性阴道炎的效果观察及价值分析  

Efficacy and Evaluation of Metronidazole Combined with Estrogen in the Treatment of Atrophic Vaginitis

作　　者：段杨平[1] DUAN Yang-ping(Zhengzhou People＇s Hospital Obstetrics and Gynecology,Zhengzhou Henan 450000,China)

机构地区：[1]郑州人民医院妇产科,河南郑州450000

出　　处：《药品评价》2018年第21期24-26,55,共4页Drug Evaluation

摘　　要：目的:探讨甲硝唑阴道给药联合雌激素治疗萎缩性阴道炎的效果观察及价值。方法:从郑州人民医院选取2016年1月到2018年2月收治的60例萎缩性阴道炎患者,按照随机抽签法将所有患者分为两组,每组30例,对照组采用甲硝唑阴道给药治疗方法,观察组采用甲硝唑阴道给药联合雌激素进行治疗。分析两组患者各项临床指标情况、生活质量、治疗效果、不良反应。结果:观察组临床指标情况优于对照组,观察组生活质量、治疗效果高于对照组,两组差异明显P<0.05。观察组和对照组患者出现的不良反应不存在明显差异P>0.05。结论:对萎缩性阴道炎患者应用甲硝唑阴道给药联合雌激素进行治疗后,取得的临床疗效较好,安全性较高,具有较大的临床使用价值。Objective To investigate the efficacy of metronidazole combined with estrogen in the treatment of atrophic vaginitis. Methods： From January 2016 to February 2018, 60 patients with atrophic vaginitis were selected from our hospital. According to the method of random drawing of lots, all patients were divided into two groups, with 30 cases in each group. The control group was treated with metronidazole vaginal administration. The observation group was treated with metronidazole vaginal administration combined with estrogen. The clinical index, quality of life, therapeutic effect and adverse reaction of the two groups were analyzed. Results： The clinical indexes in the observation group were better than those in the control group. The quality of life and therapeutic effect in the observation group were higher than those in the control group. There was no significant difference in the adverse reaction between the observation group and the control group （P〉0.05）. Conclusion： The clinical curative effect of metronidazole vaginal administration combined with estrogen in patients with atrophic vaginitis is better, with high safety, thus it has a greater clinical use value.

关 键 词：甲硝唑 雌激素 萎缩性阴道炎 疗效 

分 类 号：R984[医药卫生—药品]