人卵母细胞成熟过程中卵丘细胞与卵母细胞关系的研究进展  

Recent research progress on interaction between cumulus cells and oocytes in process of human oocyte maturation

作　　者：毛晓燕 丘瑾 MAO Xiao yan;QIU Jin(Dept.of Gynecology,Tenth People,s Hospital,Tongji University,Shanghai 200072,China;Dept.of Gynecology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200050,China)

机构地区：[1]同济大学附属第十人民医院妇产科,上海200072 [2]上海交通大学医学院附属同仁医院妇产科,上海200050

出　　处：《同济大学学报（医学版）》2018年第5期123-127,共5页Journal of Tongji University(Medical Science)

基　　金：国家重点研发计划(2017YFC1001601)

摘　　要：人卵母细胞和卵丘细胞(cumulus cell,CC)之间存在双向通讯,在卵泡内,卵母细胞的发育高度依赖于与卵丘细胞的联系。卵母细胞通过分泌有效的生长因子(oocyte-secreted factors,OSFs)介导卵丘细胞分化,卵丘细胞则通过缝隙连接传递信号并在卵泡发育的后期阶段支持卵母细胞的生长,进一步促进卵母细胞成熟和受精。本文将综述人卵母细胞成熟中卵丘细胞与卵母细胞之间的重要关系及有关作用机制,为提高体外成熟(IVM)技术中卵母细胞的质量提供新的帮助。There is a bidirectional communication between human oocytes and cumulus cells（CCs）, and the development of oocyte is highly dependent on cumulus cells. Oocytes mediate thedifferentiation of cumulus cells by oocyte-secreted factors（OSFs）, while cumulus cells transmit signalsthrough gap junctions and support the growth of ooctyes during the later stages of folliculardevelopment, further promoting oocyte maturation and fertilization. This review will focus on therelationship and mechanisms between cumulus cells and oocytes in human oocyte maturation, toprovide information for improving the quality of oocytes in vitro maturation（IVM） technology.

关 键 词：卵丘细胞 卵母细胞 糖代谢 缝隙连接 卵母细胞分泌因子 

分 类 号：R711.6[医药卫生—妇产科学]