叶酸修饰氧化石墨烯装载松针木栓酮联合微波释药的抗肿瘤研究  

Antitumor Activity of Folic Acid-modified Graphene Oxide Loaded with Pine Needle Ketone Combined with Microwave Drug Delivery

作　　者：李启照[1] 钱溪溪 陶方红 LI Qizhao;QIAN Xixi;TAO Fanghong(Department of Pharmacology,Xinhua College of Anhui,Hefei 230088,China)

机构地区：[1]安徽新华学院药学院,安徽合肥230088

出　　处：《许昌学院学报》2018年第10期34-38,共5页Journal of Xuchang University

基　　金：安徽教育厅自然科学研究项目(KJ2017A627);省级质量工程(2016sxzx021);校级质量工程(2015xqjdx04; 2015xxk06)

摘　　要：通过制备装载松针木栓酮的叶酸修饰的氧化石墨烯材料,并对其抗胃癌细胞作用进行研究.利用MTT法考察叶酸修饰的氧化石墨烯FA/GO/PNC对人胃癌细胞的抑制率;使用western blot法,研究其对胃癌细胞PI3K/Akt/m TOR信号通路的影响.结果表明,该材料对松针木栓酮负载和释药效果良好;体外实验发现其能通过影响PI3K/Akt/m TOR信号通路从而对人胃癌细胞起到较强的抑制作用.The folic acid modified graphene oxide material loaded with pine needle ketone was prepared and its anti - gastric cancer cell effect was studied.The inhibition rate of folate modified graphene oxide FA/GO/PNC on human gastric cancer cells was investigated by MTT.Western blot was used to study its effect on PI3K/Akt/mTOR signalling pathway in gastric cancer cells.The results showed that the material had good effect on the loading and releasing of pine needles.In vitro experiments showed that PI3K/Akt/mTOR signalling pathway could be affected by PI3K/Akt/mTOR, which could inhibit the growth of human gastric cancer cells.

关 键 词：氧化石墨烯 松针木栓酮 微波释药 抗肿瘤 

分 类 号：R392[医药卫生—免疫学]