血VLDL-c、UA和尿mALB水平与1型糖尿病肾病预后的研究  

Research on the relationship between VLDL-c,UA,urine mALB levels in peripheral blood and the prognosis of type 1 diabetic nephropathy

作　　者：周晓婉 任伟 ZHOU Xiao-wan;REN Wei(Anhui Provincial Hospital,Hefei 230001,Anhui)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院),安徽合肥230001

出　　处：《安徽卫生职业技术学院学报》2018年第5期96-97,99,共3页Journal of Anhui Health Vocational & Technical College

摘　　要：目的:探讨血清极低密度脂蛋白胆固醇(VLDL-c)、尿酸(UA)和尿微量白蛋白(mALB)水平与1型糖尿病肾病(T1DN)预后的关系。方法:选取早期T1DN患者100例为病例组,1型糖尿病肾病患者100例为对照组。比较两组对象治疗前血清VLDL-c、UA和尿mALB水平及与T1DN临床转归的关系。结果:病例组血清VLDL-c、UA和尿mALB水平均高于对照组(P<0.05)。血清VLDL-c、UA和尿mALB水平与肾功能负性相关,且低VLDL-c、UA、m ALB水平T1DN患者的预后明显优于高VLDL-c、UA、mALB水平组(P<0.05)。结论:血清VLDL-c、UA和尿m ALB水平与T1DN的肾损害相关,联合三项指标有助于早期DN的预后评估。Objective：To investigate the relationship between the serum levels of very low density lipoproteincholesterol （VLDL-c）, uric acid （UA）, microalbuminuria （mALB） and the prognosis of type 1 diabetic nephropathy（T1DN）. Methods：100 cases of early T1DN were selected as case group and 100 patients with type 1 diabeteswere selected as control group. The serum levels of VLDL-c, UA and urinary mALB in two groups before and aftertreatment were investigated. Results： The serum levels of VLDL-c, UA and urinary mALB in the case group weresignificantly higher than those in the control group （P〈 0.05）. In addition, serum VLDL-c, UA and urinary mALBlevels were negatively correlated with renal function, and the prognosis of patients with low VLDL-c, UA andmALB levels was significantly better than those with high VLDL-c, UA, and mALB levels （P〈 0.05）. Conclusion：The serum levels of VLDL-c, UA and urinary mALB are associated with renal impairment in T1DN. Combineddetection of the three indicators may be helpful for the early prognosis of DN.

关 键 词：极低密度脂蛋白胆固醇 尿酸 尿微量白蛋白 1型糖尿病肾病 预后 

分 类 号：R692[医药卫生—泌尿科学]