血浆ghrelin与慢性肾脏病并发症  

Serum ghrelin and chronic kidney diseases

作　　者：王泽凯 胡志娟[1] 董春霞[1] 牛凯[1] 刘冰[1] Wang Zekai;Hu Zhijuan;Dong Chunxia;Niu Kai;Liu Bing(Department of Nephrology,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北省人民医院肾内科,河北石家庄050051

出　　处：《临床荟萃》2018年第10期849-853,共5页Clinical Focus

摘　　要：维持性透析患者的并发症严重威胁其生存质量,其中营养不良、微炎症、血管病变相互联系,增加了透析患者的患病率与病死率。近些年研究的ghrelin具有促进生长激素释放的作用,而且涉及到心血管疾病、炎症的病理生理过程,同时它可以改善患者的营养状态。检测ghrelin的水平可以对维持性透析患者做出较早的干预,对临床辅助诊治有重大意义。现就ghrelin与慢性肾脏病并发症的相关性研究进展进行综述。Complications of patients treated with maintenance dialysis threaten their quality of life seriously, of which malnutrition,microinflammation and vascular lesion are interrelated, increasing the morbidity and mortality . Ghrelin can potently stimulate the release of growth hormone, improve the nutritional status of patients and is involved in the pathophysiological process of cardiovascular disease and inflammation. Detection of ghrelin concentrations could make early intervention for maintenance dialysis patients, which is of great significance for clinical auxiliary diagnosis and treatment. This paper reviews the progress on the relationship between ghrelin and chronic kidney disease complications.

关 键 词：肾疾病 营养不良 微炎症 血管病变 

分 类 号：R692[医药卫生—泌尿科学]