负压伤口疗法联合猪脱细胞真皮基质敷料治疗四肢深度烧伤创面的效果观察  

Effect of non - surgical treatment of negative pressure wound therapy combined with pig degenerative dermal matrix dressing on the repair of limb deep burn wounds

作　　者：傅勇[1] 崔光怀[1] 张国辉[1] 刘飞飞[1] Fu Yong;Cui Guanghuai;Zhang Guohui;Liu Feifei(Department of Burn Plastic Surgery,the Affiliated Hospital of Binzhou Medical College,Binzhou,Shandong 256603,China)

机构地区：[1]滨州医学院附属医院烧伤整形外科,山东省滨州256603

出　　处：《中国基层医药》2018年第19期2486-2488,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 分析负压伤口疗法（NPWT）联合猪脱细胞真皮基质（ADM）修复四肢深度烧伤创面的临床疗效.方法 选择山东省滨州医学院附属医院烧伤整形外科2015年3月21日至2016年1月18日收治的102例四肢深度烧伤创面患者,采取信封随机分组方案,分为常规组与观察组,每组51例.其中对常规组单纯采取ADM敷料修复治疗,对观察组采用NPWT＋ADM进行治疗,对比两组治疗效果.结果 观察组治疗21 d的引流液量（18.65±1.23）mL,明显少于常规组的（48.36±3.12）mL（t=63.265,P=0.000）;观察组治疗后7 d（t=153.829,P=0.000）、14 d（t=53.786,P=0.000）、21 d（t=70.763,P=0.000）创面愈合率显著高于常规组;观察组创面愈合时间（18.86±1.52）d,明显短于常规组的（28.32±1.76）d（t=29.050,P=0.000）.结论 对四肢深度烧伤创面患者采取负压伤口疗法联合猪脱细胞真皮基质修复治疗的效果显著,可明显改善患者临床症状,促进疾病的早日康复,值得实践推广.Objective To analyze the clinical efficacy of negative pressure wound therapy（NPWT）combined with pig decellularized dermal matrix（ADM）on the repair of limb deep burn wound.Methods From March 21,2015 to January 18,2016,102 patients with limb deep burn wounds in the Affiliated Hospital of Binzhou Medical College were selected,and randomly divided into conventional group and observation group,with 51 cases in cach group.The conventional group was treated with ADM dressing alone,and NPWT＋ADM was used in the experimental group.The therapeutic effect was compared between the two groups.Results The drainage fluid volume after treatment for 21d in the observation group was（18.65 ±1.23）mL,which was significantly less than that in the conventional group[（48.36 ±3.12）mL,t=63.265,P=0.000].The wound healing rates of the observation group after treatment for 7d（t=153.829,P=0.000）,14d（t=53.786,P=0.000）,21d（t=70.763,P=0.000）were significantly higher than those of the conventional group.The wound healing time of the observation group[（18.86 ±1.52）d]was significantly shorter than the conventional group [（28.32 ±1.76）d,t=29.050,P=0.000].Conclusion For patients with limb deep burn wounds,NPWT combined with ADM treatment has remarkable effect,can obviously improve the clinical symptoms,promote disease recovery,it is worthy of popularizing.

关 键 词：烧伤学 负压伤口疗法 猪脱细胞真皮基质 

分 类 号：R644[医药卫生—外科学]