血清维生素D水平对特发性膜性肾病患者的诊断价值及其相关影响因素调查研究  

Diagnostic value of serum vitamin D level in patients with idiopathic membranous nephropathy and its related influencing factors

作　　者：何洪斌[1] 张正秀[1] 张颖娟[1] 刘琳[1] 刘婷婷[1] HE Hongbin;ZHANG Zhengxiu;ZHANG Yingjuan;LIU Lin;LIU Tingting(Department of Nephrology,Panzhihua Central Hospital,Panzhihua 617000,China)

机构地区：[1]四川省攀枝花市中心医院肾内科,四川攀枝花617000

出　　处：《中国医药科学》2018年第19期20-23,共4页China Medicine And Pharmacy

基　　金：四川省医学科研青年创新课题计划项目(Q15007)

摘　　要：目的研究特发性膜性肾病患者的血清维生素D水平,分析血清维生素D水平对特发性膜性肾病患者的诊断价值及其相关影响因素。方法选取本院于2016年1～3月入本院接受诊治的116例特发性膜性肾病患者作为研究对象,根据不同的治疗方案分组,分为血液透析组(n=62)和腹膜透析组(n=54),均采用放射免疫测定法检测患者的血清维生素D水平,并检测白蛋白、碱性磷酸酶、血肌酐、血钙、高敏C反应蛋白及BNP等相关指标。对比分析两组患者的血清维生素D水平,并对其相关影响因素进行多元线性回归分析。结果两组患者的25羟维生素D平均值差异无统计学意义(P> 0.05)。血液透析组中有32例25羟维生素D缺乏(51.61%)、20例25羟维生素D降低(32.26%)、10例25羟维生素D正常(16.13%);腹膜透析组中有22例25羟维生素D缺乏(40.74%)、18例25羟维生素D降低(33.33%)、14例25羟维生素D正常(25.93%);两组25羟维生素D的缺乏程度差异无统计学意义(P> 0.05)。经多因素回归性分析,25羟维生素D与白蛋白、血肌酐、血钙、血磷、C反应蛋白及BNP指标存在一定的相关性。但结果显示,BNP与25羟维生素D之间的相关性最为显著,且呈负相关;与白蛋白、血肌酐、血钙、血磷、高敏C反应蛋白无明显相关性。结论特发性膜性肾病患者体内缺乏维生素D,其检出率较高。当维生素D水平处于不同水平时,其相关临床指标均有显著差异性,BNP与维生素D水平呈负相关,其余指标无显著相关性。Objective To study the serum vitamin D levels in patients with idiopathic membranous nephropathy and to analyze the diagnostic value of serum vitamin D levels in patients with idiopathic membranous nephropathy and related influencing factors. Methods One hundred and sixteen patients with idiopathic membranous nephropathy admitted to our hospital from January 2016 to March 2016 were selected as study subjects and divided into hemodialysis group （n=62） and peritoneal dialysis group （n=54） according to different treatment options.All patients were tested for serum vitamin D levels using radioimmunoassay,and albumin,alkaline phosphatase,serum ereatinine,serum calcium,high-sensitivity C-reactive protein,and BNP were measured.The serum vitamin D levels in the two groups were compared and analyzed.Multiple linear regression analysis was performed on the relevant factors. Results There was no significant difference in the average value of 25-hydroxy vitamin D between the two groups （P 〉 0.05）.In the hemodialysis group,there were 32 patients with 25 hydroxyvitamin D deficiency （51.61%）,20 patients with 25 hydroxy vitamin D （32.26%）,and 10 patients with normal 25 hydroxyvitamin D （16.13%）;In the peritoneal dialysis group,there were 22 eases of 25-hydroxyvitamin D deficiency （40.74%）,18 eases of 25-hydroxyvitamin D （33.33%）,and 14 eases of normal 25-hydroxyvitamin D （25.93%）;There was no significant difference in the lack of 25-hydroxyvitamin D between the two groups （P 〉 0.05）.After multivariate regression analysis, there was a certain correlation between 25-hydroxyvitamin D and albumin,serum ereatinine,serum calcium,serum phosphorus,C-reactive protein and BNP.However,the results showed that the correlation between BNP and 25 hydroxyvitamin D was the most significant and negatively correlated,and there was no significant correlation with albumin,serum ereatinine,serum calcium,serum phosphorus,and high-sensitivity C-reactive protein. Conclusion The lack of vitamin D in patients wi

关 键 词：特发性膜性肾病 血清维生素D 诊断价值 血液透析 

分 类 号：R692[医药卫生—泌尿科学]