糖尿病肾病患者血清胱抑素C和尿微量白蛋白检测水平分析  

Detection of serum levels of glutathione C and microalbuminuria in patients with diabetic nephropathy

作　　者：赵帆[1] 张枚 何訸[1] 黄亨建[1] ZHANG Mei;HE He(The laboratory medicine department,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院实验医学科,四川成都610041

出　　处：《中国实验诊断学》2018年第10期1711-1714,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清胱抑素C(Cys-C)和尿微量白蛋白(mAlb)检测水平在糖尿病肾病(DN)患者肾功能损害诊断及病情评估中的应用价值。方法回顾性分析我院在2015年1月至2017年6月期间收治的116例2型糖尿病(T2DM)患者的临床资料,根据患者24h尿微量白蛋白排泄率(UAER)分为3组,单纯糖尿病(DM组)组42例、早期DN组38例和临床DN组36例,同期将45例健康体检者作为对照组,检测并用Minitab 17统计学软件分析各组CysC、mAlb、血肌酐(SCr)、血尿素(SUrea)的结果。结果早期DN组检测Cys-C和mAlb水平高于单纯DM组、对照组,比较P<0.05差异有统计学意义。临床DN组Cys-C、mAlb、SCr和SUrea检测水平高于早期DN组、单纯DM组和对照组,比较P<0.05或P<0.01差异有统计学意义或高度统计学意义。单纯DM组和早期DN组SCr、SUrea检测水平高于对照组,比较P>0.05差异无统计学意义,Cys-C检测水平与mAlb检测水平呈正相关,r值为0.9871,P值为0.037。Cys-C和mAlb联合检测的总阳性检出率(84.5%)高于两者单项检测的总阳性检出率(分别为69.8%,61.2%),比较P<0.05差异有统计学意义。结论 Cys-C和mAlb可作为T2DM患者肾损害诊断和病情评估的检测指标,两者水平变化可反映DN患者肾损害及病情发展,联合检测对DN肾功能是早期诊断、病情评估及预后的判断具有重要的临床价值。Objective To investigate the value of serum cystatin C（Cys-C）and urinary microalbumin（mAlb）in the diagnosis and evaluation of renal function damage in diabetic nephropathy（DN）.Methods It was retrospectively analyzed that the clinical data of 116 patients with type 2 diabetes（T2 DM）treated in our hospital during the period of January 2015 to June 2017.According to 24 hours urinary albumin excretion rate（UAER）,the patients were divided into3 groups：42 patients with diabetes mellitus（DM）,38 patients with early DN and 36 patients with clinical DN.At the same time,45 healthy person were used as control group.We detected it,and the results of Cys-C,mAlb,serum creatinine（SCr）and blood urea（Surea）were analyzed by Minitab 17 software.Results The level of Cys-C and mAlb in the early DN group was higher than that of the DM group and the control group,and the difference was statistically significant（P〈0.05）.The level of Cys-C mAlb SCr and SUrea in clinical DN group washigher than that in early DN group,single DM group and control group.The difference was statistically significant or highly statistically significant（P〈0.05 or P〈0.01）.The level of SCr SUrea in DM group and early DN group was higher than that in control group.The difference was not statistically significant（P〉0.05）.The Cys-C and the mAlb were positively correlated（r=0.9871,P=0.037）.The total positive rate of Cys-C and mAlb was 84.5%,which ishigher than that of single test（69.8% and 61.2%）.The difference was statistically significant（P〈0.05）.Conclusion Cys-C and mAlb can be used as indicators for the diagnosis and assessment of renal damage in patients with T2 DM.The changes of their level can reflect the renal damage and progression of patients with DN.Combined detection has important clinical value in early diagnosis,evaluation and prognosis of DN renal function.

关 键 词：糖尿病肾病 胱抑素C 尿微量白蛋白 回顾性分析 

分 类 号：R587.2[医药卫生—内分泌]