体外冲击波联合玻璃酸钠注射治疗膝关节骨性关节炎的疗效研究  

Efficacy research of extracorporeal shock wave combined with Sodium Hyaluronate Injection in the treatment of knee osteoarthritis

作　　者：潘科[1] 漆伟[1] 刘奕[1] 徐立新[1] 徐贞杰[1] 向连[1] PAN Ke, QI Wei, LIU Yi, et al.(Chongqing Three Gorges Central Hospital, Chongqing 404000, China)

机构地区：[1]重庆三峡中心医院,404000

出　　处：《中国实用医药》2018年第29期25-27,共3页China Practical Medicine

基　　金：重庆市万州区科学技术项目(项目编号:201503012)

摘　　要：目的观察玻璃酸钠注射配合体外冲击波治疗膝关节骨性关节炎(KOA)的疗效。方法 50例膝关节骨性关节炎患者,采用完全随机法分为对照组和治疗组,每组25例。对照组患者给予常规治疗+玻璃酸钠治疗,治疗组患者给予常规治疗+玻璃酸钠联合体外冲击波治疗。比较两组患者治疗前及治疗1、2、3、4、5周西部安大略麦克马斯特大学骨关节炎指数可视化量表(WOMAC)评分。结果对照组患者治疗3、4、5周WOMAC评分低于治疗前,治疗4、5周WOMAC评分低于治疗3周,差异具有统计学意义(P<0.05);治疗组患者治疗2、3、4、5周WOMAC评分低于治疗前,治疗3、4、5周WOMAC评分低于治疗2周,差异具有统计学意义(P<0.05)。治疗2、3、4、5周,治疗组患者WOMAC评分分别为(122.00±21.01)、(83.00±11.26)、(77.00±10.06)、(79.00±10.03)分,低于对照组的(180.00±21.56)、(126.00±24.01)、(97.00±10.11)、(96.00±10.09)分,差异具有统计学意义(P<0.05)。治疗组治疗2周见效,治疗3周后疗效达高峰,后趋于稳定;对照组治疗3周见效,治疗4周后疗效达高峰,后趋于稳定。结论玻璃酸钠注射配合体外冲击波治疗可提高膝关节骨性关节炎的疗效。Objective To explore the efficacy of Soudium Hyaleronate Injection combined with extracorporeal shock wave in the treatment of knee osteoarthritis（KOA）. Methods A total of 50 patients with KOA were divided into control group and treatment group by completely random method, 25 cases in each group. Patients in the control group were given conventional therapy and Sodium Hyaluronate treatment, patients in the treatment group were given conventional therapy and Sodium Hyaluronate combined with extracorporeal shock wave. The scores of Western Ontario MacMaster University Osteoarthritis index（WOMAC） before treatment and after 1 week, 2, 3, 4 and 5 weeks of treatment between the two groups were compared. Results The WOMAC scores of the control group after 3, 4, 5 weeks of treatment were significantly lower than that before treatment, and the WOMAC scores after 4 and 5 weeks of treatment were significantly lower than that after 3 weeks of treatment, the differences were statistically significant（P〈0.05）. The WOMAC scores of the treatment group after 2, 3, 4 and 5 weeks of treatment were significantly lower than that before treatment, and the WOMAC scores after 3, 4 and 5 weeks were significantly lower than that after 2 weeks of treatment, the differences were statistically significant（P〈0.05）. After 2, 3, 4, and 5 weeks of treatment, the WOMAC scores of the treatment group were（122.00± 21.01） scores,（83.00±11.26） scores,（77.00±10.06） scores and（79.00±10.03） scores respectively, which were significantly lower than（180.00±21.56） scores,（126.00±24.01） scores,（97.00±10.11） scores,（96.00± 10.09） scores of the control group, the differences were statistically significant（P〈0.05）. The treatment group was effective for 2 weeks, the curative effect reached the peak after 3 weeks, then tended to be stable; the control group was effective for 3 weeks, the curative effect reached the peak after 4 weeks, and then tended to be stable. Conclusion Soudium Hyaleronate Inje

关 键 词：膝关节骨性关节炎 玻璃酸钠注射液 体外冲击波 联合 

分 类 号：R684.3[医药卫生—骨科学]