染料木黄酮在放射损伤防护中的研究进展  

A review of the protective effects of genistein against radiation injuries

作　　者：逄志骏 何磊[1] 周继明[1] 马晓雯[1] 张旭涛[1] 王昭维 李萌[1] PANG Zhijun;HE Leia;ZHOU Jiming;MA Xiaowen;ZHANG Xutao;WANG Zhaowei;LI Meng(Department of Biopharmaceutics,School of Pharmacy,The Fourth Military Medical University,Xi＇an 710032,China;Clinical Laboratory,401 General Military Hospital,Qingdao 266000,China)

机构地区：[1]第四军医大学药学系生物制药学教研室,西安710032 [2]解放军第四0一医院检验科,青岛266000

出　　处：《辐射研究与辐射工艺学报》2018年第5期1-6,共6页Journal of Radiation Research and Radiation Processing

基　　金：基金资助:国家自然科学基金项目(81673020)资助~~

摘　　要：随着核事故的增加和未来战争形势的需要,各国日益重视放射损伤引发的危害,对放射损伤保护药物的研究也从未止步。放射损伤保护药物能够减少电离辐射导致的细胞或机体损伤,在放射防护体系中发挥重要作用。天然活性成分染料木黄酮由于其较强的抗放射性及低毒副作用,成为了抗放射药物的研究热点,美国对其在军事放射损伤防护方面的研究已进入临床试验阶段。本文综述了近年来染料木黄酮的抗放射研究进展。In recent years, with the increase of nuclear accidents and the possible need for future war, countries are paying increased attention to the harm caused by radiation injury, and research on drugs that can offer radiation protection is ongoing. Anti-radiation drugs can reduce cell or body damage caused by ionizing radiation and play an important role in radiation protection system. Genistein, a natural active component, has become a hotspot in the research of anti-radiation drugs because of its strong anti-radioactivity and fewer toxic side effects. The research on military radiation injury in the United States has reached the clinical trial stage. In this paper, the recent advances with respect to radioprotective activities of genistein are reviewed.

关 键 词：辐射损伤 染料木黄酮 辐射防护剂 综述 

分 类 号：Q691[生物学—生物物理学] TL71[核科学技术—辐射防护及环境保护]