2-溴-4,5-二甲氧基苯甲醛高选择性脱甲基反应  

Highly Selective Demethylation of 2-Bromo-4,5-dimethoxy Benzaldehyde

作　　者：姜芳[1] 方维臻[1] 陆群[1] JIANG Fang;FANG Wei-zhen;LU Qun(School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China)

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031

出　　处：《合成化学》2018年第11期854-855,862,共3页Chinese Journal of Synthetic Chemistry

基　　金：四川省科技支撑计划(2015FZ001)

摘　　要：以藜芦醛为起始原料,经溴化反应制得中间体2-溴-4,5-二甲氧基苯甲醛,选择性脱除甲基合成了6-溴香草醛和6-溴异香草醛,收率分别为87.0%和80.2%,其结构经~1H NMR确证。6-Bromovanillin and 6-bromoisovanillin were synthesized by selective demethylation of 2-bromo-4,5-dimethoxy benzaldehyde, which was prepared by bromination reaction of veratrylaldehyde. The yields were 87.0% and 80.2%, respectively. The structures were confirmed by 1 H NMR.

关 键 词：藜芦醛 选择性脱甲基 6-溴香草醛 6-溴异香草醛 合成 

分 类 号：O625.4[理学—有机化学]