铜绿假单胞菌耐药机制的研究及新治疗策略  

Research on the Drug Resistance Mechanism of Pseudomonas Aeruginosa and the New Treatment Strategy

作　　者：魏新素[1] 刘永太 秦勇[1] WEI Xin-su;LIU Yong-tai;QIN Yong(Pneumology Department,the First Division Hospital of the Xinjiang Production and Construction Corps,Xinjiang Akesu,843000;Clinical Laboratory,the First Division Hospital of the Xinjiang Production and Construction Corps,Xinjiang Akesu,843000)

机构地区：[1]新疆生产建设兵团第一师医院呼吸科,新疆阿克苏843000 [2]新疆生产建设兵团第一师医院检验科,新疆阿克苏843000

出　　处：《农垦医学》2018年第4期349-353,共5页Journal of Nongken Medicine

基　　金：新疆生产建设兵团第一师师市科研项目(2017YL04)

摘　　要：铜绿假单胞菌(Pseudomonas aeruginosa,PA)是临床分离出的假单胞菌最常见的菌株,可致多种感染,其耐药性已变得越来越普遍。耐药机制包括:天然耐药性、获得耐药性和适应性耐药。针对PA感染,不断有新的治疗方法出现,如:外排泵抑制剂(efflux pump inhibitors,EPIs)、噬菌体、纳米技术、针对PA感染的疫苗等。本文着重综述近年来有关铜绿假单胞菌毒力、耐药率、耐药机制研究文献,并对PA感染新的治疗方法做分析。Pseudomonas aeruginosa is the most common strain of pseudomonas,which can cause multiple infections,and its resistance had become more and more common.Resistance mechanisms were including： natural resistance,acquisition of resistance and adaptive resistance.New treatments were emerged for PA infections,such as efflux pump inhibitors（EPIs）,phages,nanotechnology,and vaccines for PA infections,etc.New treatment methods were analyzed though reviewing the recent literature on virulence,resistance rate and resistance mechanism of pseudomonas aeruginosa.

关 键 词：铜绿假单胞菌 耐药 治疗 

分 类 号：R446.5[医药卫生—诊断学]