长效胰岛素联合口服降糖药治疗2型糖尿病的疗效与安全性分析  

Efficacy and safety analysis of protamine zinc insulin combined with oral antidiabetic drugs in the treatment of type 2 diabetes mellitus

作　　者：严广德 张志丹[1] YAN Guang-de;ZHANG Zhi-dan(Outpatient Department,The People＇s Hospital of Huaiji County,Huaiji 526400,China)

机构地区：[1]怀集县人民医院门诊部,526400

出　　处：《中国现代药物应用》2018年第21期79-80,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨长效胰岛素联合口服降糖药治疗2型糖尿病的临床疗效与安全性。方法 150例2型糖尿病患者,随机分为对照组和观察组,各75例。对照组患者给予口服格列吡嗪分散片治疗,观察组患者在对照组基础上联合甘精胰岛素治疗。比较两组患者的治疗效果、不良反应发生率及治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)水平。结果治疗前,两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平比较差异无统计学意义(P>0.05);治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为92%,明显高于对照组的71%,差异有统计学意义(P<0.05)。观察组不良反应发生率3%低于对照组的13%,差异有统计学意义(P<0.05)。结论长效胰岛素联合口服降糖药治疗2型糖尿病的疗效比单一口服降糖药更加明显,更有利于控制患者的血糖水平,并且不良反应发生率较低,可见联合方案足够安全可靠,应用价值高。Objective To investigate the clinical efficacy and safety of protamine zinc insulin combined with oral antidiabetic drugs in the treatment of type 2 diabetes mellitus. Methods A total of 150 patients with type 2 diabetes mellitus were randomly divided into control group and observation group, 75 cases in each group. Patients in the control group were treated with Glipizide Dispersible Tablets, patients in the observation group were treated with Insulin Glargine on the basis of the control group. The curative effect, incidence of adverse reactions and levels of fasting plasma glucose （FPG）, 2 h postprandial plasma glucose （2 h PG） and glycosylated hemoglobin （HbA1c） before and after treatment between the two groups were compared. Results There were no significant differences in the FPG, 2 h PG and HbA1c between the two groups before treatment （P〉0.05）. After treatment, the FPG, 2 h PG and HbA1c of the two groups were significantly lower than those before treatment, and the above indexes of the observation group were significantly lower than those of the control group, the differences were statistically significant （P〈0.05）. The total effective rate of the observation group was 92%, which was significantly higher than 71% of the control group, the difference was statistically significant （P〈0.05）. The incidence of adverse reactions in the observation group was 3%, which was significantly lower than 13% in the control group, the difference was statistically significant （P〈0.05）. Conclusion The efficacy of protamine zinc insulin combined with oral antidiabetic drugs in the treatment of type 2 diabetes mellitus is more effective than single oral antidiabetic drugs, more conducive to the control of blood glucose levels in patients, and the incidence of adverse reactions is low, indicating that the combined program is safe and reliable enough, and with higher application value.

关 键 词：长效胰岛素 口服降糖药 2型糖尿病 疗效与安全 

分 类 号：R587.1[医药卫生—内分泌]