氢化可的松治疗过敏性紫癜的效果及对血清sVCAM-1和LTB4水平的影响  

Effect of hydrocortisone in the treatment of anaphylactoid purpura and its effect on serum sVCAM-1 and LTB4 levels

作　　者：张娟 王吉利 ZHANG Juan;WANG Ji-li(Pharmacy Department,Xi＇an No.5 Hospital,Xi＇an 710082,China)

机构地区：[1]西安市第五医院药剂科,陕西西安710082

出　　处：《临床医学研究与实践》2018年第31期50-51,共2页Clinical Research and Practice

摘　　要：目的探讨氢化可的松治疗过敏性紫癜的效果及对血清可溶性血管细胞黏附分子-1(sVCAM-1)和白细胞三烯(LTB4)水平的影响。方法选取我院2015年2月至2017年2月收治的72例过敏性紫癜患儿,将其分为两组,每组36例。对照组患儿予以常规治疗,研究组在对照组基础上予以氢化可的松治疗,比较两组患儿的疗效。结果研究组患儿治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组血清sVCAM-1、LTB4水平均显著降低,且研究组sVCAM-1、LTB4水平显著低于对照组,差异均具有统计学意义(P<0.05)。两组患儿均没有出现不良反应。结论氢化可的松治疗过敏性紫癜临床疗效良好,能有效抑制炎症发生,临床应用具有一定安全性。Objective To investigate the effect of hydrocortisone in the treatment of anaphylactoid purpura and its effect on serum soluble vascular cell adhesion molecule-1 （sVCAM-1） and leukocyte three ene （LTB4） level. Methods A total of 72 cases of anaphylactoid purpura treated in our hospital from February 2015 to February 2017 were selected and divided into two groups, with 36 cases in each group. The control group was given conventional treatment, the study group was treated with hydrocortisone on the basis of the control group, and the clinical efficacy of the two groups were compared. Results The total effective rate of the study group was significantly higher than that of the control group （P〈0.05）. After treatment, the levels of sVCAM-1 and LTB4 in the two groups significantly decreased, and those in the study group were significantly lower than those in the control group （P〈0.05）. No adverse reactions were found in the two groups. Conclusion Hydrocortisone has a good clinical effect in the treatment of anaphylactoid purpura, with can effectively inhibit the occurrence of inflammation, and it has a certain safety in clinical application.

关 键 词：氢化可的松 过敏性紫癜 可溶性血管细胞黏附分子-1(sVCAM-1) 白细胞三烯(LTB4) 

分 类 号：R725.5[医药卫生—儿科]