磷钼杂多酸光度法测定药物中对乙酰氨基酚含量  

Spectrophotometric Determination of Paracetamol in Pharmaceutical Sample by Phosphorus Molybdenum Heteropoly Acid

作　　者：温欣荣[1] 涂常青[1] 黄韶锋 WEN Xinrong;TU Changqing;HUANG Shaofeng(College of Chemistry and Environment,Jiaying University,Meizhou,Guang dong,514015,China)

机构地区：[1]嘉应学院化学与环境学院,广东梅州514015

出　　处：《化学世界》2018年第10期652-658,共7页Chemical World

摘　　要：在H2SO4介质中,由H2PO-4与Mo7O6-24反应生成的磷钼杂多酸可以被对乙酰氨基酚定量地还原为最大吸收波长717nm的磷钼蓝,通过测定磷钼蓝的吸光度可间接测定对乙酰氨基酚的含量,据此建立了磷钼杂多酸分光光度法测定对乙酰氨基酚的方法。对乙酰氨基酚在0.004 000～0.040 00mg/mL范围内与A呈良好的线性关系,线性回归方程为A=0.044 9+24.689c (mg/mL),线性相关系数r=0.999 7。方法用于药物中对乙酰氨基酚的含量测定,结果与药典法一致。Phosphorus molybdenum heteropoly acid obtained from the reaction between H2 PO-4 and Mo7 O6-24 could be reduced by paracetamol to from phosphorus molybdenum blue with a maximum absorption wavelength at 717 nm in H2 SO4.The content of paracetamol could be determined by measuring the absorbance of phosphorus molybdenum blue so as to establish a novel method for the spectrophotometric determination of paracetamol by phosphorus molybdenum heteropoly acid.A good linear relationship was obtained between the absorbance and the concentration of paracetamol in the range of 0.004 000～0.040 00 mg/mL and the equation of the linear regression is A =0.044 9＋24.689 c（mg/mL）,with a linear correlation coefficient of 0.999 7.This proposed method has been successfully applied for the determination of paracetamol in pharmaceutical sample,and the results agree well with those by pharmacopoeial method.

关 键 词：对乙酰氨基酚 磷钼杂多酸 磷钼蓝 分光光度法 

分 类 号：O657.32[理学—分析化学]