益母草注射液应用于妇科宫腔镜手术的临床观察  

Clinical observation of herba leonuri injection in gynecologic hysteroscopy

作　　者：陈德新[1] 腾银成 蔡雁[3] 刘香环 常军[1] 赵志刚 CHEN De-xin;TENG Yin-cheng;CAI Yan;LIU Xiang-huan;CHANG Jun;ZHAO Zhi-gang(Sichuan Maternity and Child Health Care Hospital,Chengdu,Sichuan 610036,China)

机构地区：[1]四川省妇幼保健院妇科,四川成都610036 [2]上海市第六人民医院妇科,上海200233 [3]哈尔滨医科大学附属第四医院妇科,黑龙江哈尔滨150001 [4]山东省立第三医院妇科,山东济南250031

出　　处：《中国临床研究》2018年第10期1409-1412,共4页Chinese Journal of Clinical Research

基　　金：四川省科技支撑计划项目(2014SZ0139);四川省中医药管理局科技支撑项目(2016ZY008);四川省科技成果转化示范项目(2018CC0108)

摘　　要：目的探讨益母草注射液应用于妇科宫腔镜手术的安全性和有效性。方法选择2017年1月至8月行宫腔镜手术的患者182例,按入院先后随机分到试验组和对照组,试验组95例,对照组87例。于麻醉后,试验组手术前肌内注射益母草注射液2 ml+缩宫素注射液静脉滴注10 U,术后2 h肌内注射益母草注射液2 ml,以后每12 h注射1次,2 ml/次,连续3次;对照组手术前缩宫素静脉滴注20 U,以后每12 h注射1次,10 U/次,连续3次。以两组术中出血量、术后出血量和出血时间作为有效性指标;以两组不良反应和术中血压情况作为安全性指标。结果与对照组比较,试验组更有助于减少手术的术中出血量[(18. 48±10. 95) ml vs (22. 38±14. 31) ml]、术后出血量[(12. 49±9. 33) ml vs (15. 65±11. 36) ml]及术后的累计出血时间[(2. 12±0. 74) d vs (3. 19±2. 01) d],差异均有统计学意义(P <0. 05,P <0. 01);试验组的术中收缩压[(8. 03±6. 39) mm Hg vs (13. 28±8. 57) mm Hg]、舒张压[(5. 24±4. 16) mm Hg vs(7. 97±6. 58) mm Hg]的最大波动值明显更小,差异均有统计学意义(P均<0. 01)。试验组不良反应发生率稍低于对照组(0 vs 5. 75%),但差异无统计学意义(P> 0. 05)。结论益母草注射液联合缩宫素注射液应用于妇科宫腔镜手术安全、有效,有利于宫腔镜手术的开展。Objective To investigate the safety and efficacy of herba leonuri injection in gynecologic hysteroscopy.Methods A total of 182 patients undergoing hysteroscopic surgery from January to August 2017 were randomly divided into experimental group（n = 95） and control group（n = 87） according to the sequence of hospital admission. After anaesthesia,intravenous drip of Oxytocin injection 10 U and intramuscular injection of herba leonuri 2 ml were given before operation,and intramuscular injection of herba leonuri 2 ml was administered at postoperative 2 hours,and then 1 time per12 h（a total of 3 injections） in experimental group. In control group,the intravenous drip of oxytocin 20 U was given before operation,then 1 time per 12 h（10 U/time,3 times continuously）. The intraoperative blood loss,postoperative bleeding loss and bleeding time was observed as indicators of effectiveness,and adverse reactions and intraoperative blood pressure was observed as safety indicators in two groups. Results Compared with control group,the intraoperative bleeding[（18. 48 ± 10. 95） ml vs（22. 38 ± 14. 31） ml],postoperative bleeding volume[（12. 49 ± 9. 33） ml vs（15. 65 ± 11. 36）ml] and postoperative cumulative bleeding time [（2. 12 ± 0. 74） d vs（3. 19 ± 2. 01） d] statistically decreased in experimental group（P〈0.05,P〈0.01）. The maximum fluctuations of systolic pressure [（8. 03 ± 6. 39） mm Hg vs（13. 28 ± 8. 57） mm Hg],diastolic pressure [（5. 24 ± 4. 16） mm Hg vs（7. 97 ± 6. 58） mm Hg]were significantly lower in experimental group than those in control group（all P〈0.01）. The incidence of adverse reaction（0 vs 5. 75%） was slightly lower in experimental group than that in control group,but there was no significantly difference（P〈0.05）.Conclusion Application of herba leonuri injection combined with Oxytocin is safe and effective in gynecologic hysteroscopy and is conducive to the development of hysteroscopic surgery.

关 键 词：益母草注射液 缩宫素 宫腔镜手术 出血量 出血时间 不良反应 

分 类 号：R713[医药卫生—妇产科学] R969[医药卫生—临床医学]